STUDY OF INTRAFAMILIAL TRANSMISSION OF SMALLPOX
STUDY OF INTRAFAMILIAL TRANSMISSION OF SMALLPOX
复制标题
DOI：
10.1093/oxfordjournals.aje.a121326
复制
发表时间：
1971-01-01
影响因子：
5
通讯作者：
MCCRUMB, FR
中科院分区：
文献类型：
--
作者：
HEINER, GG;FATIMA, N;MCCRUMB, FR
Heiner，G. G.（国际医学研究所，马里兰州大学医学院，巴尔的摩，马里兰州）21201），N.法蒂玛和F. R.小麦克拉姆A study of intrafamilial transmission of smallpox.Amer J Epidem94：316-326，1971.-在1968-1970年期间西巴基斯坦农村47起天花暴发的464名家庭接触者中进行了流行病学研究。未接种疫苗者的二次发病率为70.3%，既往接种疫苗者为4.8%，总体发病率为19.6%。发病率的变化与接触者暴露前的疫苗接种状况、暴露模式、年龄、疫苗接种状况和指示病例的疾病严重程度的差异显著相关。既往接种过疫苗的继发病例死亡率和发病率降低。结果表明，在亲密接触的条件下，一个村庄的化合物，大多数接触者被感染，并在以前接种疫苗的接触者的发展明显的疾病取决于免疫水平的接触和病毒的挑战强度。
Heiner, G. G. (Institute of International Medicine, Univ. of Maryland School of Medicine, Baltimore, Md. 21201), N. Fatima and F. R. McCrumb, Jr. A study of intrafamilial transmission of smallpox.Amer J Epidem94: 316–326, 1971.—An epidemiologic study was conducted among the 464 family contacts of the first cases in 47 smallpox outbreaks in rural West Pakistan during the period 1968–1970. Secondary attack rates were 70.3% in unvaccinated and 4.8% in previously vaccinated contacts, with an overall rate of 19.6%. Variations in attack rates were significantly associated with differences in pre-exposure vaccination status of the contact, in exposure patterns and in age, vaccination status, and severity of illness of the index case. Previously vaccinated secondary cases experienced reduced mortality and morbidity. Results indicate that, under the conditions of intimate exposure of a village compound, the majority of contacts become infected, and that the development of overt disease in previously vaccinated contacts depends both upon the level of immunity of the contact and upon the intensity of the virus challenge.