Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients.
Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients.
复制标题
鱼油可以改变血液透析患者的脂质并降低血小板聚集性。
作者：
P. Rylance;M. Gordge;R. Saynor;V. Parsons;M. Weston
血液透析患者因心血管原因死亡的发生率极高，部分与血脂和血小板异常有关。然而，爱斯基摩人的心肌梗塞发病率较低，并且富含富含 omega-3 多不饱和脂肪酸的鱼类。因此，我们研究了含有 3.6 克 omega-3 多不饱和脂肪酸二十碳五烯酸的鱼油 MaxEPA 对血液透析患者血脂和血小板功能的影响。治疗 8 周后，甘油三酯下降 35%，高密度脂蛋白 (HDL) 胆固醇上升 10%，HDL2 胆固醇分数上升 36%，HDL2:HDL3 胆固醇比率上升 54%。血小板对二磷酸腺苷和胶原蛋白的聚集显着减少。活化的全血凝血时间从 141 秒延长至 153 秒，69% 的患者表现出因子 VIII 相关抗原减少，该抗原在血液透析患者中通常升高，被认为是内皮损伤的标志。血压从147/82下降到124/74。因此，我们已经证明，二十碳五烯酸的膳食补充剂对血脂、血小板和血压产生潜在的有益影响，并可能有助于预防高危血液透析患者的动脉粥样硬化，从而预防心血管死亡。
Haemodialysis patients have an exceptionally high incidence of death from cardiovascular causes, related in part to abnormalities of lipids and platelets. Eskimos, however, have a low incidence of myocardial infarction and have a high dietary intake of fish, rich in omega-3 polyunsaturated fatty acids. We have, therefore, studied the effect of a fish oil MaxEPA, containing 3.6 g of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on lipids and platelet function in haemodialysis patients. Following 8 weeks of therapy there was a 35% fall in triglycerides, a 10% rise of high-density lipoprotein (HDL) cholesterol, a 36% rise of HDL2 cholesterol fraction and a 54% rise of the HDL2:HDL3 cholesterol ratio. The platelet aggregation to adenosine diphosphate and collagen was significantly reduced. The activated whole-blood clotting time was prolonged from 141 to 153 s, and 69% of patients showed a reduction of factor VIII related antigen which is usually elevated in haemodialysis patients and is thought to be a marker of endothelial damage. The blood pressure fell from 147/82 to 124/74. We have thus shown that a dietary supplement of eicosapentaenoic acid produces potentially beneficial effects on lipids, platelets, and blood pressure and may help to protect against atheroma and thus cardiovascular mortality in high-risk haemodialysis patients.