Self-Reported Adverse Drug Reactions and Related Resource Use
Self-Reported Adverse Drug Reactions and Related Resource Use
复制标题
自我报告的药物不良反应和相关资源使用
DOI：
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发表时间：
1992
影响因子：
39.2
通讯作者：
R. Wallace
中科院分区：
文献类型：
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作者：
E. Chrischilles;Ellen T. Segar;R. Wallace
目的
描述65岁及以上人群中自我报告的药物不良反应（ADR）的发生率和卫生资源后果及其与自我感知健康、使用的药物数量和年龄的关系。
设计
对特定人群的调查。
参与者
居住在两个爱荷华州县的3170名65岁及以上的非住院人员。
测量
ADR报告（使用开放式问卷调查）;涉及的药物名称;反应和相关卫生资源使用的描述;自我感知的健康状况（第一次年度随访时）;和药物数量（基线访谈）。
结果
10%（95% CI，8.97 - 11.09）的受访者报告了一个或多个ADR。四分之三报告ADR的受访者联系了医生。其中，一半表示已下令进行实验室检查，7%报告因反应而住院。仅高龄与女性风险降低相关;男性的类似趋势在统计学上不显着。然而，健康状况较差的人和那些报告既往使用药物最多的人最有可能报告反应。
结论
在这项对非住院老年人的研究中，高龄似乎与自我报告的ADR风险增加无关。我们无法确定年龄最大的受访者中ADR报告的减少是否代表ADR发生率的真正减少或ADR检测和报告能力的改变。当预测到老年社区居住的美国人口时，每年有220万次医生就诊，110万次实验室检查和146，000次住院治疗可能由ADR引起。
OBJECTIVE
To describe the incidence and health resource consequences of self-reported adverse drug reactions (ADRs) and their relation to self-perceived health, number of medications used, and age in a geographically based population 65 years of age and older.
DESIGN
A survey of a defined population.
PARTICIPANTS
Three thousand, one hundred seventy noninstitutionalized persons 65 years of age and older residing in two Iowa counties.
MEASUREMENTS
Reports of ADRs (elicited using an open-ended questionnaire); names of drugs involved; descriptions of reactions and related health resource use; self-perceived health status (at the first annual follow-up); and number of medications (from the baseline interview).
RESULTS
Ten percent (95% CI, 8.97 to 11.09) of respondents reported one or more ADRs. Three quarters of respondents who reported ADRs contacted a physician. Of these, half indicated that a laboratory test had been ordered, and 7% reported a hospitalization due to the reaction. Advanced age alone was associated with decreased risk in women; a similar trend in men was not statistically significant. However, persons with poorer health status and those who reported the greatest prior use of medications were most likely to report reactions.
CONCLUSIONS
In this study of noninstitutionalized elderly persons, advanced age did not appear to be associated with increased risk for self-reported ADRs. We could not determine whether the decrease in ADR reports among the oldest respondents represented true diminished ADR occurrence or altered ADR detection and reporting capabilities. When projected to the elderly community-dwelling U.S. population, 2.2 million annual physician visits, 1.1 million laboratory tests, and 146,000 hospitalizations may result from ADRs.
影响因子：
5.6
作者：
P. L. Colsher;R. B. Wallace
通讯作者：
P. L. Colsher;R. B. Wallace