Usefulness of contrast-enhanced magnetic resonance imaging for evaluating solitary pulmonary nodules
Usefulness of contrast-enhanced magnetic resonance imaging for evaluating solitary pulmonary nodules
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DOI：
10.1102/1470-7330.2008.0009
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发表时间：
2008-01-01
期刊：
影响因子：
4.9
通讯作者：
Fujimoto, Kiminori
中科院分区：
文献类型：
--
作者：
Fujimoto, Kiminori
摘要孤立性肺结节(SPN)的评估对放射科医生提出了挑战。胸部计算机断层扫描(CT)被认为是评估SPN的形态和胸腔内扩散的标准技术。尽管核磁共振成像(MRI)在SPN中的临床作用仍然有限，但在胸部疾病的MRI方面已经积累了相当多的经验。动态MRI和动态CT有助于鉴别良性和恶性SPN(尤其是结核球和错构瘤)。此外，动态MRI有助于评估肿瘤血管、间质和血管内皮生长因子的表达，并有助于预测周围型肺癌患者的生存结果。这些优点使动态MRI成为一种很有前景的方法和潜在的生物标记物，用于表征肿瘤对抗血管生成治疗的反应以及预测治疗后的生存结果。
Abstract Evaluation of solitary pulmonary nodules (SPNs) poses a challenge to radiologists. Chest computed tomography (CT) is considered the standard technique for assessing morphologic findings and intrathoracic spread of an SPN. Although the clinical role of magnetic resonance imaging (MRI) for SPNs remains limited, considerable experience has been gained with MRI of thoracic diseases. Dynamic MRI and dynamic CT are useful for differentiating between malignant and benign SPNs (especially tuberculomas and hamartomas). Furthermore, dynamic MRI is useful for assessing tumor vascularity, interstitium, and vascular endothelial growth factor expression, and for predicting survival outcome among patients with peripheral pulmonary carcinoma. These advantages make dynamic MRI a promising method and a potential biomarker for characterizing tumor response to anti-angiogenic treatment as well as for predicting survival outcomes after treatment.