CARD9 Signaling in the Innate Immune Response
CARD9 Signaling in the Innate Immune Response
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DOI：
10.1196/annals.1443.024
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Ruland, Juergen
中科院分区：
文献类型：
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作者：
Ruland, Juergen
CARD9是一种含有caspase募集结构域的信号蛋白，在树突状细胞和巨噬细胞中高表达。过去两年的研究已经确定CARD9是天然免疫的中央调节因子。最具代表性的是CARD9的S在髓系细胞中具有ITAM受体或ITAM偶联受体下游的功能，包括其在抗真菌模式识别受体Dectin-1下游的重要作用。在ITAM受体途径中，CARD9将受体近端脾酪氨酸激酶SYK的激活与典型的核因子-kappaB途径偶联。此外，CARD9还参与了p38和JNK激酶的激活，并且可以在胞质模式识别受体下游发挥作用。CARD9信号介导哺乳动物对选定的真菌、细菌和病毒的先天免疫反应，并可以启动和形成适应性免疫。本文将对CARD9信号及其在先天性免疫反应中的作用的研究现状进行综述。
CARD9 is a caspase recruitment domain-containing signaling protein that is highly expressed in dendritic cells and in macrophages. Work over the last two years has identified CARD9 as a central regulator of innate immunity. Best characterized is CARD9's function downstream of ITAM-bearing or ITAM-coupled receptors in myeloid cells, including its essential role downstream of the antifungal pattern-recognition receptor Dectin-1. In the ITAM receptor pathway, CARD9 couples receptor proximal splenic tyrosine kinase SYK activation to the canonical NF-kappa B pathway. In addition, CARD9 is involved in the activation of p38 and JNK kinases and it can function downstream of cytosolic pattern-recognition receptors. CARD9 signaling mediates mammalian innate immune responses against selected fungi, bacteria, and viruses and can prime and shape adaptive immunity. This review will summarize current: knowledge on CARD9 signaling and its function in the innate immune response.