Detection of renal allograft rejection using blood oxygen level-dependent and diffusion weighted magnetic resonance imaging: a retrospective study.
Detection of renal allograft rejection using blood oxygen level-dependent and diffusion weighted magnetic resonance imaging: a retrospective study.
复制标题
使用血氧水平依赖性和扩散加权磁共振成像检测肾同种异体移植排斥：一项回顾性研究
DOI：
10.1186/1471-2369-15-158
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发表时间：
2014-10-01
期刊：
影响因子：
2.3
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Liu G;Han F;Xiao W;Wang Q;Xu Y;Chen J
研究背景急性排斥反应（AR）和急性肾小管坏死（ATN）是早期移植肾功能障碍的主要原因。血氧水平依赖性磁共振成像 (BOLD MRI) 和扩散加权 (DW) MRI 可以通过分别测量 R2* 或表观扩散系数 (ADC) 来提供有关氧生物利用度和水扩散变化的有价值的信息。我们的目的是确定BOLD MRI和DW MRI在检测同种异体肾移植受者早期同种异体移植物功能障碍原因中的价值。方法对50例接受已故供体肾移植的患者进行分析，其中肾功能正常患者35例（对照组），AR患者10例，ATN患者5例。通过 BOLD MRI 测量皮质 R2* (CR2*) 和髓质 R2* (MR2*)。 DW MRI 中使用了 10 个扩散梯度 b 值（0、5、10、20、50、100、200、400、800、1200s/mm2）。测量肾皮质 (CADC) 和肾髓质 (MADC) 的 ADC 值。 CADC和MADCl在低b值（b≤ 200 s/mm2）下测量，而CADC和MADCh在高b值（b> 200 s/mm2）下测量。结果AR组MR2*（18.2± 1.5/s）显着低于对照组（23.8± 5.0/s）， p = 0.001）和ATN组（25.8 ± 5.0/s， p = 0.004)。 CADCl、MADCl、CADChor、MADChin AR组较对照组有降低的趋势。 AR组与ATN组ADC值无差异。结论BOLD MRI是检测同种异体肾急性排斥反应的一种有价值的方法。
BackgroundAcute rejection (AR) and acute tubular necrosis (ATN) are main causes of early renal allograft dysfunction. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) and Diffusion weighted (DW) MRI can provide valuable information about changes of oxygen bioavailability and water diffusion by measuring R2* or apparent diffusion coefficient (ADC) respectively. We aimed to determine the value of BOLD MRI and DW MRI in detecting causes for early allograft dysfunction in renal allograft recipients.MethodsFifty patients received renal allografts from deceased donors were analyzed, including 35 patients with normal renal function (control group), 10 AR patients and 5 ATN patients. Cortical R2* (CR2*) and medullary R2* (MR2*) were measured by BOLD MRI. Ten diffusion gradientbvalues (0, 5, 10, 20, 50, 100, 200, 400, 800, 1200s/mm2) were used in DW MRI. ADC values were measured in renal cortex (CADC) and medulla (MADC). CADCland MADClwere measured under lowbvalues (b≤ 200 s/mm2), while CADChand MADChwere measured under highbvalues (b> 200 s/mm2).ResultsMR2* was significantly lower in AR group (18.2 ± 1.5/s) than control group (23.8 ± 5.0/s, p = 0.001) and ATN group (25.8 ± 5.0/s, p = 0.004). There was a tendency of lower levels on CADCl, MADCl, CADChor MADChin AR group than in control group. There were no differences on ADC values between AR group and ATN group.ConclusionsBOLD MRI was a valuable method in detection of renal allografts with acute rejection.