Using porous bioceramic scaffolds to model healthy and osteoporotic bone
Using porous bioceramic scaffolds to model healthy and osteoporotic bone
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DOI：
10.1016/j.jeurceramsoc.2016.01.011
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发表时间：
2016-08-01
影响因子：
5.7
通讯作者：
Vitale-Brovarone, Chiara
中科院分区：
文献类型：
--
作者：
Baino, Francesco;Caddeo, Silvia;Vitale-Brovarone, Chiara
生物陶瓷在临床上用作可植入材料，以减轻疼痛并恢复身体中患病或受损硬组织的功能。老年人的骨骼特别容易退化和骨折，因为随着年龄的增长，骨量和强度会减少（骨质疏松症）。本研究工作的目标是设计和制造具有不同孔隙/支柱特征的3-D生物陶瓷支架，其可以模拟健康骨和骨质疏松骨的结构。以SiO_2-P_2O_5-CaO-MgO-Na_2 O-K_2 O生物活性玻璃（CEL_2）为原料，采用海绵复型法制备支架。系统地改变关键工艺参数，并评估其对支架结构和机械特性的影响。应用细胞固体力学理论研究了孔隙率与强度的关系，并建立了模型。这些玻璃陶瓷支架为骨再生方法开辟了新的前景，并可作为模型基质，用于更准确地研究骨病理学。(C)2016爱思唯尔有限公司版权所有。
Bioceramics are clinically used as implantable materials to alleviate pain and restore function to diseased or damaged hard tissues in the body. Bone is especially vulnerable to deterioration and fracture in elderly people because of a loss of bone mass and strength with age (osteoporosis). The goal of this research work is to design and fabricate 3-D bioceramic scaffolds with different pore/strut features that can mimic the architecture of both healthy and osteoporotic bone. The scaffolds were fabricated by sponge replica method using a SiO2-P2O5-CaO-MgO-Na2O-K2O bioactive glass (CEL2) as starting material. Key processing parameters were systematically varied and their influence on the architectural and mechanical features of the scaffolds was assessed. Porosity-strength relationship was studied and modelled by using the theory of cellular solid mechanics. These glass-ceramic scaffolds open new perspectives for bone regenerative approaches and could act as model substrates for a more accurate investigation of bone pathologies. (C) 2016 Elsevier Ltd. All rights reserved.