Bilateral damage to the mammillo-thalamic tract impairs recollection but not familiarity in the recognition process: A single case investigation
Bilateral damage to the mammillo-thalamic tract impairs recollection but not familiarity in the recognition process: A single case investigation
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DOI：
10.1016/j.neuropsychologia.2007.03.025
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Caltagirone, C.
中科院分区：
文献类型：
--
作者：
Carlesimo, G. A.;Serra, L.;Caltagirone, C.
局限于海马体的局灶性损伤可能会导致识别缺陷，其特征是记忆受损和熟悉度保留之间的分离。在这里，我们报告了一名双侧丘脑前部损伤的遗忘症患者的病例，该患者的神经心理学特征表明存在这种分离。我们假设这种局灶性损伤涉及所谓的延迟和布里昂环路，理论上该环路可以促进情景记忆过程，但与海马损伤患者的解剖水平不同。使用两个独立的实验范式（记住/知道和信心接受者操作特征[ROC]）并招募一组性别和年龄匹配的健康对照，我们证明该患者的认知缺陷是由于正常熟悉过程的选择性记忆障碍所致。该患者接受了一项临时脑部 MRI 研究，并对他的 MR 图像进行了定量分析。组织损伤双侧延伸至乳头丘脑束，丘脑内侧核团完全保存。我们的研究结果支持这样的观点，即针对内侧颞叶不同子区域假设的相同功能专业化也可能延伸到丘脑。该案例将根据其支持最新理论的含义进行讨论，这些理论将记忆和熟悉度视为与不同神经回路相关的独立过程。 (c) 2007 Elsevier Ltd. 保留所有权利。
Focal damage confined to the hippocampus may result in recognition deficits characterized by a dissociation between impaired recollection and preserved familiarity. Here, we report a single case of an amnesic patient with bilateral damage to the anterior part of the thalamus, who presented with a neuropsychological profile suggesting such a dissociation. We hypothesized that this focal damage involved the so-called Delay and Brion's circuit, which has been theorized to subserve episodic memory processes, but at a different anatomical level than in patients with hippocampal lesions. Using two independent experimental paradigms (remember/know and confidence receiver operating characteristics [ROC]) and recruiting a sex- and age-matched group of healthy controls, we demonstrated that this patient's recognition deficits were due to a selective impairment of recollection with a normal familiarity process. The patient underwent an ad hoc brain MRI study, and a quantitative analysis of his MR images was performed. Tissue damage extended bilaterally to the mammillo-thalamic tract, with complete preservation of the medio-dorsal thalamic nuclei. Our findings support the idea that the same functional specialization hypothesized for the different sub-regions of the mesial temporal lobe might also extend to the thalamus. This case will be discussed in light of its implications in support of recent theories, which regard recollection and familiarity as independent processes associated with different neural circuits. (c) 2007 Elsevier Ltd. All rights reserved.