Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii
Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii
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DOI：
10.1007/s12272-011-0807-7
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发表时间：
2011-09
影响因子：
6.7
通讯作者：
Hong-Sheng Wang;Ling Sun;Yue-Hu Wang;Ya-Na Shi;G. Tang;Fu-wei Zhao;Hong-mei Niu;Chun-lin Long;Ling Li
中科院分区：
文献类型：
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作者：
Hong-Sheng Wang;Ling Sun;Yue-Hu Wang;Ya-Na Shi;G. Tang;Fu-wei Zhao;Hong-mei Niu;Chun-lin Long;Ling Li
一种新的二氢黄酮，5-羧甲基-7,4'-二羟基黄酮 (1)，及其葡萄糖苷 5-羧甲基-7,4'-二羟基黄酮酮-7-O-β-d-吡喃葡萄糖苷 (2)，以及一种新的单萜葡萄糖苷，(4Z,6E)-2,7-二甲基-8-羟基辛基-4,6-二烯酸8-O-β-d-吡喃葡萄糖苷(3)，从卷柏全草中分离得到。它们的结构通过光谱方法和化学转化测定。评估了化合物2在高浓度胰岛素和葡萄糖诱导的正常和胰岛素抵抗L6肌细胞中增强葡萄糖消耗的能力。在存在胰岛素(1 nM)的情况下，浓度为0.1 μM的化合物2使胰岛素抵抗细胞(但正常细胞中没有)的葡萄糖消耗增加15.2 ± 3.3% (p< 0.01)。
A new dihydroflavone, 5-carboxymethyl-7,4′-dihydroxyflavonone (1), and its glucoside 5-carboxymethyl-7,4′-dihydroxyflavonone-7-O-β-d-glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-β-d-glucopyranoside (3), were isolated from the whole plants ofSelaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound2was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% (p< 0.01) by compound2at a concentration of 0.1 μM in the presence of insulin (1 nM).