MicroRNA Regulation of Atherosclerosis.
MicroRNA Regulation of Atherosclerosis.
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DOI：
10.1161/circresaha.115.306300
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发表时间：
2016-02-19
影响因子：
20.1
通讯作者：
Moore KJ
中科院分区：
文献类型：
--
作者：
Feinberg MW;Moore KJ
动脉粥样硬化及其伴随的临床并发症，如心肌梗死、中风和外周动脉疾病，是西方社会发病率和死亡率的主要原因。在生物化学和生物力学刺激下，动脉粥样硬化病变的形成是由一系列细胞类型、炎症介质和剪切应力参与的。在过去的十年中，microrna作为一种进化上保守的非编码小rna出现，在动脉粥样硬化的一系列病理生理细胞效应和分子信号通路中起着重要的调节和“微调”作用。越来越多的研究揭示了mirna在调节关键信号通路和脂质稳态途径中的重要性，这些途径改变了动脉粥样硬化斑块进展和消退的平衡。在这篇综述中，我们重点介绍了microrna介导的动脉粥样硬化进展和消退的当前范式。我们提供了miRNAs在诊断中用于检测冠状动脉疾病和临床事件严重程度增加的潜在应用的最新进展。最后，我们提供了miRNA递送领域的治疗机会和挑战的观点。
Atherosclerosis and its attendant clinical complications such as myocardial infarction, stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in western societies. In response to biochemical and biomechanical stimuli, atherosclerotic lesion formation occurs from the participation of a range of cell types, inflammatory mediators, and shear stress. Over the past decade, microRNAs have emerged as evolutionarily conserved, non-coding small RNAs that serve as important regulators and “fine-tuners” of a range of pathophysiological cellular effects and molecular signaling pathways involved in atherosclerosis. Accumulating studies reveal the importance of miRNAs in regulating key signaling and lipid homeostasis pathways that alter the balance of atherosclerotic plaque progression and regression. In this review, we highlight current paradigms of microRNA-mediated effects in atherosclerosis progression and regression. We provide an update on the potential use of miRNAs diagnostically for detecting increasing severity of coronary disease and clinical events. Finally, we provide a perspective on therapeutic opportunities and challenges for miRNA delivery in the field.