Lifestyle and health-related quality of life of men with prostate cancer managed with active surveillance
Lifestyle and health-related quality of life of men with prostate cancer managed with active surveillance
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DOI：
10.1016/j.urology.2005.07.056
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发表时间：
2006-01-01
期刊：
影响因子：
2.1
通讯作者：
Ornish, D
中科院分区：
文献类型：
--
作者：
Daubenmier, JJ;Weidner, G;Ornish, D
目标.评估生活方式对选择主动监测的早期前列腺癌患者的健康相关生活质量（HR-QOL）、感知压力和自我报告的性功能的影响。共有44名干预和49名常规护理对照参与者参加了一项随机临床试验，研究生活方式改变对前列腺癌进展的影响。干预措施包括低脂纯素饮食、锻炼和压力管理。参与者在基线和12个月时完成了医学结局研究简表-36健康状况调查（一种精神和身体HR-QOL的测量）、感知压力量表、加州大学洛杉矶分校的性功能子量表、前列腺癌指数和生活方式行为测量（以产生总体生活方式指数）。使用重复测量的方差分析对数据进行分析。采用多元线性回归分析生活方式与生活质量的关系。在12个月时，与对照组相比，干预组参与者的生活方式有了显着改善。各组和各时间点的生活质量评分均较高。然而，更健康的生活方式与基线时更好的QOL相关。两组中报告生活方式更健康的参与者也报告了更好的精神和身体HR-QOL和性功能。此外，随着时间的推移，生活方式改善的参与者表现出增强的身体HR-QOL和减少感知压力。选择积极监测早期前列腺癌的男性能够全面改变生活方式。虽然在这个样本中平均生活质量已经很高，但改善生活方式的人进一步提高了他们的生活质量。
Objectives. To assess the impact of lifestyle on health-related quality of life (HR-QOL), perceived stress, and self-reported sexual function in men with early-stage prostate cancer electing active surveillance.Methods. A total of 44 intervention and 49 usual-care control participants were enrolled in a randomized clinical trial examining the effects of lifestyle changes on prostate cancer progression. The intervention consisted of a low-fat, vegan diet, exercise, and stress management. Participants completed the Medical Outcomes Study Short Form-36 Health Status Survey (a measure of mental and physical HR-QOL), the Perceived Stress Scale, the Sexual Function subscale of the University of California, Los Angeles, Prostate Cancer Index, and measures of lifestyle behaviors (to yield an overall lifestyle index) at baseline and 12 months. The data were analyzed using analysis of variance for repeated measures. The relationship between lifestyle and QOL was also analyzed using multiple linear regression analyses.Results. Intervention participants had significantly improved their lifestyle compared with controls at 12 months. The quality-of-life scores were high across groups and time points. However, a healthier lifestyle was related to better QOL at baseline. Participants in both groups who reported a healthier lifestyle also reported better mental and physical HR-QOL and sexual function. Furthermore, participants whose lifestyle improved over time showed enhanced physical HR-QOL and decreased perceived stress.Conclusions. Men who choose active surveillance for early-stage prostate cancer are able to make comprehensive lifestyle changes. Although the average QOL was already high in this sample, individuals who improved their lifestyle enhanced their QOL further.