Role of substance P in stress-derived degranulation of dermal mast cells in mice
Role of substance P in stress-derived degranulation of dermal mast cells in mice
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DOI：
10.1016/j.jdermsci.2005.12.004
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发表时间：
2006-04-01
影响因子：
4.6
通讯作者：
Suzuki, H
中科院分区：
文献类型：
--
作者：
Kawana, S;Liang, ZF;Suzuki, H
背景：神经、免疫系统和炎症反应之间的相互作用。最近的研究表明，多种应激源可诱导动物真皮肥大细胞脱颗粒。目的：本研究旨在证实P物质（SP）参与应激条件下真皮肥大细胞脱颗粒。方法：利用通讯盒系统，对小鼠进行足部冲击应激（FS）和心理应激（PS），测定真皮肥大细胞脱颗粒率、SP阳性神经纤维数量和SP含量变化。研究了非肽NK1受体拮抗剂对这些变化的抑制作用。结果：FS和PS均显着增强真皮肥大细胞的脱颗粒并增加SP阳性神经纤维的数量。 FS显着降低真皮SP含量，而PS则增加SP。腹腔注射NK1受体拮抗剂可抑制这些变化。结论：认为神经末梢释放的SP在真皮肥大细胞脱颗粒过程中具有重要作用。这项研究的结果表明，速激肽受体拮抗剂对加重的应激性皮炎具有抑制作用。 (c) 2005 年日本皮肤病研究学会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Background: The interaction between nerve the immune system and inflammatory responses. Recent studies have shown that various stressors can induce degranulation of dermal mast cells in animals.Objectives: This study was conducted to confirm that substance P (SP) was involved in the degranulation of dermal mast cells in stress conditions.Methods: Using a communication box system, foot shock stress (FS) and psychological stress (PS) were administered to mice and the degranulation rate of dermal mast cells, the number of SP-positive nerve fibers and changes in SP content were determined. The inhibitory effect of a non-peptide NK1-receptor antagonist on these changes was investigated.Results: Both FS and PS significantly enhanced the degranulation of dermal mast cells and increased the number of SP-positive nerve fibers. FS significantly decreased dermal SP content whereas SP was increased by PS. These changes were inhibited by intraperitoneal, injection of NK1 receptor antagonist.Conclusions: It was considered that SP released from the nerve ending, had an important role in the degranulation of dermal mast cells. Results of this study suggest that the tachykinin receptor antagonist exhibited an inhibitory effect on aggravated stress-induced dermatitis. (c) 2005 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.