Synergetic Effect of Mo6 Clusters and Gold Nanoparticles on the Photophysical Properties of Both Components.
Synergetic Effect of Mo6 Clusters and Gold Nanoparticles on the Photophysical Properties of Both Components.
复制标题
Mo6 团簇和金纳米颗粒对两种组分光物理性质的协同效应。
DOI：
10.1002/chem.202004618
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Novikova ED
中科院分区：
文献类型：
--
作者：
Novikova ED
光动力疗法和光热疗法(分别为PDT和PTT)是多模式抗癌疗法(即联合疗法)的有前途的候选者，因为它们的作用基于通常不能被癌细胞抵抗的机制，即分别产生高氧化性氧物种和高温。本文报道了将八面体钼簇合物作为潜在的光催化转移剂和等离子体球形金纳米颗粒(AuNPs)作为光催化转移剂的杂化材料。团簇的光电子能谱和AuNPs的表面等离子体共振带的部分重叠促进了光活性成分之间的能量转移，从而导致了它们的光物理性质的协同增强。具体地说，通过仔细选择团簇和金纳米颗粒之间的间距，与类似但无金的颗粒相比，团簇的发光和光敏性能显著增加。另一方面，团簇络合物促进了金颗粒向热的转化，从而提高了激光照射下的升温速率。
Photodynamic and photothermal therapies (PDT, and PTT, respectively) are promising candidates for multimodal anticancer therapies (i.e., combinations of therapies), since their action is based on mechanisms that generally cannot be resisted by cancer cells, that is, generation of highly oxidizing oxygen species and high temperature, respectively. Herein, hybrid materials that combine octahedral molybdenum clusters as potential PDT agents and plasmonic spherical gold nanoparticles (AuNPs) as PTT agents are reported. Partial overlap of the photoemission spectrum of the cluster and the surface plasmon resonance band of the AuNPs facilitates energy transfer between the photoactive components, which resulted in synergetic enhancement of their photophysical properties. Specifically, by careful selection of the spacing between the cluster and the gold nanoparticle, a significant increase in luminescence and photosensitizing properties of the cluster was achieved in comparison with similar, but gold‐free, particles. On the other hand, the cluster complex facilitated energy conversion to heat by gold particles and hence increased the heating rate under laser irradiation.