Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.
Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.
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DOI：
10.1167/iovs.15-18886
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发表时间：
2016-07-01
影响因子：
4.4
通讯作者：
Izatt JA
中科院分区：
文献类型：
--
作者：
Kuo AN;Verkicharla PK;McNabb RP;Cheung CY;Hilal S;Farsiu S;Chen C;Wong TY;Ikram MK;Cheng CY;Young TL;Saw SM;Izatt JA
通过磁共振成像（MRI）进行的后眼形状评估用于研究近视。我们测试的假设，光学相干断层扫描（OCT），作为一种替代，可以测量后眼的形状类似于MRI。分析了先前作为新加坡眼科疾病流行病学研究的一部分获得的黄斑谱域OCT和脑部MRI图像。MRI和OCT图像中的右眼被自动分割。光学相干断层扫描分割校正光学和显示失真，需要生物统计数据。将分割拟合到球体和椭圆体以获得后眼曲率半径（Rc）和非球面度（Qxz）。使用配对t检验检验通过MRI和OCT测量的Rc和Qxz的差异。比较了使用Qxz的扁长或扁圆的分类分配。纳入了52例等效球镜屈光度为+0.50至-5.38的受试者（67.8 ± 5.6岁）。MRI和原始OCT后眼Rc之间的平均配对差异为24.03 ± 46.49 mm（P = 0.0005）。对于校正后的OCT图像，Rc差异降至−0.23 ± 2.47 mm（P = 0.51）。MRI和OCT非球面度之间的差异Qxz为−0.052 ± 0.343（P = 0.28）。然而，分类一致性仅为中度（κ = 0.50）。Rc和Qxz的畸变校正OCT测量值与MRI无统计学显著差异，尽管中度分类一致性表明个体差异仍然存在。本研究提供的证据表明，通过畸变校正，基于办公室的无创OCT可能替代MRI用于后眼形状的研究。
Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical coherence tomography segmentations were corrected for optical and display distortions requiring biometry data. The segmentations were fitted to spheres and ellipsoids to obtain the posterior eye radius of curvature (Rc) and asphericity (Qxz). The differences in Rc and Qxz measured by MRI and OCT were tested using paired t-tests. Categorical assignments of prolateness or oblateness using Qxz were compared. Fifty-two subjects (67.8 ± 5.6 years old) with spherical equivalent refraction from +0.50 to −5.38 were included. The mean paired difference between MRI and original OCT posterior eye Rc was 24.03 ± 46.49 mm (P = 0.0005). For corrected OCT images, the difference in Rc decreased to −0.23 ± 2.47 mm (P = 0.51). The difference between MRI and OCT asphericity, Qxz, was −0.052 ± 0.343 (P = 0.28). However, categorical agreement was only moderate (κ = 0.50). Distortion-corrected OCT measurements of Rc and Qxz were not statistically significantly different from MRI, although the moderate categorical agreement suggests that individual differences remained. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape.