Alpha-human atrial natriuretic peptide (alpha-hANP) prevents pulmonary edema induced by arachidonic acid treatment in isolated perfused lung from guinea pig.
Alpha-human atrial natriuretic peptide (alpha-hANP) prevents pulmonary edema induced by arachidonic acid treatment in isolated perfused lung from guinea pig.
复制标题
α-人心房钠尿肽 (α-hANP) 可预防豚鼠离体灌注肺中花生四烯酸治疗引起的肺水肿。
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
H. Matsuo
中科院分区：
文献类型：
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作者：
N. Inomata;N. Ohnuma;M. Furuya;Y. Hayashi;Y. Kanai;T. Ishihara;T. Noguchi;H. Matsuo
采用离体肺灌注模型，研究α -人心房钠素肽（α - hanp）对肺水肿的保护作用。α - hanp （1.7 ~ 22 ng/ml或0.56 ~ 7.3 nM）可预防50微克花生四烯酸每隔30 min经肺动脉重复给药豚鼠离体肺引起的水肿。由于肺匀浆中α - hanp的有效浓度接近ANP受体结合的Kd值，因此认为α - hanp的消肿作用是受体介导的。
Protective effect of alpha-human atrial natriuretic peptide (alpha-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of alpha-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 micrograms of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of alpha-hANP was considered to be receptor mediated because the effective concentration was close to the Kd value of the binding of the ANP receptors in the lung homogenate.