Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples
Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples
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DOI：
10.1111/and.12268
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发表时间：
2015-04-01
期刊：
影响因子：
2.4
通讯作者：
Koner, B. C.
中科院分区：
文献类型：
--
作者：
Bhongade, M. B.;Prasad, S.;Koner, B. C.
本研究旨在探讨心理应激对不育夫妇男性生殖激素及精液质量的影响。采用医院焦虑抑郁量表（HADS）对70例不育夫妇的男性配偶进行心理应激水平评估，采用电化学发光法测定血清总睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）水平，采用ELISA法测定血清促性腺激素释放激素（GnRH）水平。根据WHO指南进行精液分析。其中19例（27%）HADS焦虑和抑郁评分为8分（HADS评分异常）。HADS异常者血清总睾酮低于正常者，FSH、LH高于正常者。血清总睾酮与HADS呈负相关，LH和FSH呈正相关。GnRH没有随着压力或睾酮水平的变化而变化。HADS异常者的精子数、活力和形态正常的精子均较低。精子数与总睾酮呈正相关，与FSH、LH呈负相关。精子活力和形态异常与睾酮水平降低、LH和FSH水平升高有关。心理应激首先降低血清总睾酮水平，其次升高血清LH和FSH水平，改变精液质量。压力管理是男性不育症的必要条件。
The present study evaluated the effect of psychological stress on male fertility hormones and seminal quality in male partner of infertile couples. Seventy male partners of infertile couples were evaluated for level of psychological stress using Hospital Anxiety and Depression Score (HADS) questionnaire, serum total testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH) by electrochemiluminescence assay and serum GnRH by ELISA. Seminal analysis was performed as per WHO guideline. Nineteen (27%) of them had HADS anxiety and depression score 8 (abnormal HADS score). The persons having abnormal HADS had lower serum total testosterone, higher serum FSH and LH than those of persons having normal HADS. Serum total testosterone correlated negatively with HADS, but LH and FSH correlated positively. There was no change in GnRH with the change in stress or testosterone levels. Sperm count, motility and morphologically normal spermatozoa were lower in persons having abnormal HADS. Sperm count correlated positively with total testosterone and negatively with FSH and LH. Abnormal sperm motility and morphology were related to lower testosterone and higher LH and FSH levels. Psychological stress primarily lowers serum total testosterone level with secondary rise in serum LH and FSH levels altering seminal quality. Stress management is warranted for male infertility cases.