Predictors of supervised-exercise adherence during breast cancer chemotherapy
Predictors of supervised-exercise adherence during breast cancer chemotherapy
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DOI：
10.1249/mss.0b013e318168da45
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发表时间：
2008-06-01
期刊：
影响因子：
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通讯作者：
Mckenzie, Donald C.
中科院分区：
文献类型：
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作者：
Courneya, Kerry S.;Segal, Roanne J.;Mckenzie, Donald C.
在癌症治疗期间坚持锻炼是困难的，但很少有研究检查这种锻炼的预测因素。在这里，我们报告了乳腺癌化疗期间坚持监督运动训练的预测因素。研究方法：在埃德蒙顿、渥太华和温哥华开始辅助化疗的乳腺癌患者（N = 242）在化疗期间被随机分配到常规护理组（n = 82）、监督抗阻运动组（n = 82）或监督有氧运动组（n = 78）。收集了标准人口统计学、医疗、行为、健身和心理社会变量以及计划行为理论中的动机变量的基线数据。通过客观的出勤记录评估依从性。结果：坚持有监督的运动是70.2%。单变量分析表明，锻炼坚持性和地点/中心之间存在显著或边缘显著相关性（r = 0.30; P < 0.001），VO 2峰值（r=0.21;P=0.008），肌力（r = 0.21;P= 0.008），体脂百分比（r = -0.21;P=0.012）、疾病分期（r=0.17; P= 0.031）、文化程度（r= 0.15; P = 0.053）、抑郁（r = -0.14; P = 0.073）和吸烟（r= -0.14; P = 0.081）。在多变量分析中，地点/中心（β = 0.28; P = 0.001）、VO 2峰值（β = 0.19; P = 0.016）、疾病分期（β = 0.18; P = 0.015）和抑郁（β = -0.16; P = 0.033）仍然具有显著性，并解释了锻炼依从性的21%的方差。温哥华的参与者具有更高的有氧健身能力，更先进的疾病阶段和更低的抑郁症，实现了更好的坚持。结论：坚持监督运动训练的预测独特的方面的位置/中心，疾病阶段，有氧健身，抑郁症，但不是动机变量。在我们的试验中，位置/中心可能是在监督锻炼期间收到的一对一关注量的代理。这些发现可能对改善乳腺癌化疗期间的依从性具有意义。
Purpose: Exercise adherence is difficult during cancer treatments, but few studies have examined the predictors of such exercise. Here, we report the predictors of adherence to supervised exercise training during breast cancer chemotherapy. Methods: Breast cancer patients (N = 242) initiating adjuvant chemotherapy in Edmonton, Ottawa, and Vancouver were randomly assigned to usual care (n = 82), supervised resistance exercise (n = 82), or supervised aerobic exercise (n = 78) for the duration of their chemotherapy. Baseline data on standard demographic, medical, behavioral, fitness, and psychosocial variables as well as motivational variables from the Theory of Planned Behavior were collected. Adherence was assessed by objective attendance records. Results: Adherence to supervised exercise was 70.2%. Univariate analyses indicated significant or borderline significant associations between exercise adherence and location/center (r = 0.30; P < 0.001), VO2peak (r=0.21;P=0.008), muscular strength (r = 0.21;P= 0.008), percent body fat (r = -0.21;P=0.012), disease stage (r=0.17; P= 0.031), education (r= 0.15; P = 0.053), depression (r = -0.14; P = 0.073), and smoking (r= -0.14; P = 0.081). In multivariate analysis, location/center (beta = 0.28; P = 0.001), VO2peak (beta = 0.19; P = 0.016), disease stage (beta = 0.18; P = 0.015), and depression (beta = -0.16; P = 0.033) remained significant and explained 21% of the variance in exercise adherence. Participants in Vancouver, with higher aerobic fitness, more advanced disease stage, and lower depression, achieved better adherence. Conclusion: Adherence to supervised exercise training was predicted by unique aspects of the location/center, disease stage, aerobic fitness, and depression but not motivational variables. Location/center in our trial may have been a proxy for the amount of one-on-one attention received during supervised exercise. These findings may have implications for improving adherence during breast cancer chemotherapy.