Host-pathogen interactions in bacterial meningitis.
Host-pathogen interactions in bacterial meningitis.
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DOI：
10.1007/s00401-015-1531-z
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发表时间：
2016-02
影响因子：
12.7
通讯作者：
Valentin-Weigand P
中科院分区：
文献类型：
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作者：
Doran KS;Fulde M;Gratz N;Kim BJ;Nau R;Prasadarao N;Schubert-Unkmeir A;Tuomanen EI;Valentin-Weigand P
细菌性脑膜炎是一种毁灭性的疾病，在世界范围内发生，多达一半的幸存者留下永久性的神经系统后遗症。由于脑膜病原体的内在特性及其引起的宿主反应，感染可引起相对特定的病变和临床综合征，这是由于干扰受影响的神经系统组织的功能而引起的。发病机制基于复杂的宿主-病原体相互作用，其中一些是某些细菌特有的，而另一些则是不同病原体共有的。在这篇综述中，我们总结了在理解这些相互作用所涉及的分子和细胞事件方面取得的最新进展。我们重点关注选定的主要病原体：肺炎链球菌、无乳链球菌（B 组链球菌）、脑膜炎奈瑟菌和大肠杆菌 K1，还包括一种被忽视的人畜共患病原体：猪链球菌。这些神经侵袭性病原体代表了宿主与病原体相互作用的共同主题，例如粘膜屏障的定植和入侵、在血流中的存活、通过血脑和血脑脊液屏障易位进入中枢神经系统，以及诱导脑膜炎症，影响软脑膜、蛛网膜和蛛网膜下腔。
Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host–pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host–pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood–brain and blood–cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.