Radioresistance of Deinococcus radiodurans: Functions necessary to survive ionizing radiation are also necessary to survive prolonged desiccation
Radioresistance of Deinococcus radiodurans: Functions necessary to survive ionizing radiation are also necessary to survive prolonged desiccation
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DOI：
10.1128/jb.178.3.633-637.1996
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发表时间：
1996-02-01
影响因子：
3.2
通讯作者：
Battista, JR
中科院分区：
文献类型：
--
作者：
Mattimore, V;Battista, JR
41电离辐射敏感菌株的耐辐射异常球菌进行了评估，他们的生存能力6周的干燥。与野生型D相比，所有这些都表现出在再水化后生存力的实质性损失。耐辐射的从干燥培养物中检测染色体DNA，发现DNA损伤呈时间依赖性增加，这是通过DNA双链断裂的增加来测量的。证据表明D.耐辐射生物的电离辐射抗性是偶然的，是这种生物体适应常见生理应激（脱水）的结果。
Forty-one ionizing radiation-sensitive strains of Deinococcus radiodurans were evaluated for their ability to survive 6 weeks of desiccation. All exhibited a substantial loss of viability upon rehydration compared with wild-type D. radiodurans. Examination of chromosomal DNA from desiccated cultures revealed a time-dependent increase in DNA damage, as measured by an increase in DNA double-strand breaks. The evidence presented suggests that D. radiodurans' ionizing radiation resistance is incidental, a consequence of this organism's adaptation to a common physiological stress, dehydration.