The potential role of rodents in the enzootic cycle of Rift Valley fever virus in Senegal
The potential role of rodents in the enzootic cycle of Rift Valley fever virus in Senegal
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DOI：
10.1016/s1286-4579(00)00334-8
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发表时间：
2000-04-01
影响因子：
5.8
通讯作者：
Gonzalez, JP
中科院分区：
文献类型：
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作者：
Gora, D;Yaya, T;Gonzalez, JP
在塞内加尔的7个地点捕获了14种野生啮齿动物（214只）。Arvicanthis niloticus和Mastomys erythroleucus是最常采集的物种（占总捕获量的77.2%）。对所有啮齿动物进行了抗裂谷热病毒（RVFV）抗体检查;所有采样物种的患病率为3.8%，因物种和地点而异。在14种啮齿动物中，有4种动物有RVFV抗体阳性，分别为：家鼠（1/2）、乳鼠（13.5%）、黄胸鼠（13.5%）、黄胸鼠（13.5%）和黄胸鼠（13.5%）。niloticus（4.3%）和M.红白血病（2.4%）。最高流行率的抗RVFV抗体记录在塞内加尔河三角洲的地方病流行区，在理查德托尔（9.6%）。A. niloticus和M.用两种RVFV菌株对100只红白血病小鼠和一种实验室繁殖的小鼠进行实验性接种，并检查病毒血症、疾病、血清转化和死亡率。A. niloticus和M.红白血病病毒表现出对感染的有限抗性，因此可能允许病毒在这些动物中复制，并使这些物种成为自然界中RVFV维持周期中可能的宿主。(C)2000年，Elsevier SAS科学与医学版。
Wild rodents (214) of fourteen species were trapped at seven sites in Senegal. Arvicanthis niloticus and Mastomys erythroleucus were among the most frequently collected species (77.2% of total capture). All rodents were examined for the presence of anti-Rift Valley fever virus (RVFV) antibody; the prevalence over all sampled species was 3.8%, varying widely with respect to species and location. Four of 14 species of rodents were found to have anti-RVFV antibodies: Rattus rattus (one positive of two tested) Mastomys huberti (13.5%), A. niloticus (4.3%), and M. erythroleucus (2.4%). The highest prevalence of anti-RVFV antibody was recorded within the enzootic area of the Senegal River delta, at Richard Toll (9.6%). A. niloticus and M. erythroleucus and a strain of laboratory-bred mice were experimentally inoculated with two strains of RVFV and examined for viremia, illness, seroconversion and mortality. A. niloticus and M. erythroleucus demonstrated a limited resistance to infection, thus potentially allowing for the replication of virus in these animals and making these species possible candidates as hosts in the maintenance cycle of RVFV in nature. (C) 2000 Editions scientifiques et medicales Elsevier SAS.