The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation.
The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation.
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DOI：
10.3389/fmolb.2023.1117850
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发表时间：
2023
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
A variety of glycan structures cover the surface of all cells and are involved in myriad biological processes, including but not limited to, cell adhesion and communication, protein quality control, signal transduction and metabolism, while also being intimately involved in innate and adaptive immune functions. Immune surveillance and responses to foreign carbohydrate antigens, such as capsular polysaccharides on bacteria and surface protein glycosylation of viruses, are the basis of microbial clearance, and most antimicrobial vaccines target these structures. In addition, aberrant glycans on tumors called Tumor-Associated Carbohydrate Antigens (TACAs) elicit immune responses to cancer, and TACAs have been used in the design of many antitumor vaccine constructs. A majority of mammalian TACAs are derived from what are referred to as mucin-type O-linked glycans on cell-surface proteins and are linked to the protein backbone through the hydroxyl group of either serine or threonine residues. A small group of structural studies that have compared mono- and oligosaccharides attached to each of these residues have shown that there are distinct differences in conformational preferences assumed by glycans attached to either “unmethylated” serine or ß-methylated threonine. This suggests that the linkage point of antigenic glycans will affect their presentation to the immune system as well as to various carbohydrate binding molecules (e.g., lectins). This short review, followed by our hypothesis, will examine this possibility and extend the concept to the presentation of glycans on surfaces and in assay systems where recognition of glycans by proteins and other binding partners can be defined by different attachment points that allow for a range of conformational presentations.
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影响因子：
4.3
作者：
Portella G;Battistini F;Orozco M
通讯作者：
Orozco M
影响因子：
3.7
作者：
Carvalho AT;Gouveia L;Kanna CR;Wärmländer SK;Platts JA;Kamerlin SC
通讯作者：
Kamerlin SC
影响因子：
7.3
作者：
Kaczmarek P;Keay SK;Tocci GM;Koch KR;Zhang CO;Barchi JJ Jr;Grkovic D;Guo L;Michejda CJ
通讯作者：
Michejda CJ
影响因子：
8
作者：
Coelho H;Rivas ML;Grosso AS;Diniz A;Soares CO;Francisco RA;Dias JS;Compañon I;Sun L;Narimatsu Y;Vakhrushev SY;Clausen H;Cabrita EJ;Jiménez-Barbero J;Corzana F;Hurtado-Guerrero R;Marcelo F
通讯作者：
Marcelo F
影响因子：
6.8
作者：
de las Rivas, Matilde;Lira-Navarrete, Erandi;Hurtado-Guerrero, Ramon
通讯作者：
Hurtado-Guerrero, Ramon