IS TOBACCO A RISK FACTOR FOR CHRONIC-PANCREATITIS AND ALCOHOLIC CIRRHOSIS
IS TOBACCO A RISK FACTOR FOR CHRONIC-PANCREATITIS AND ALCOHOLIC CIRRHOSIS
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DOI：
10.1136/gut.32.11.1392
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发表时间：
1991-11-01
期刊：
影响因子：
24.5
通讯作者：
SARLES, H
中科院分区：
文献类型：
--
作者：
BOURLIERE, M;BARTHET, M;SARLES, H
在一项病例对照研究中，对1975年至1987年间103例酒精性肝硬化男性患者、145例慢性胰腺炎患者和264例对照组的酒精摄入量和烟草使用情况进行了评估。 慢性胰腺炎患者明显比肝硬化患者年轻（平均（SD）年龄41.92（2.4）± 60.9（11.6）岁）。 在慢性胰腺炎患者中，94%的患者既吸烟又饮酒，而肝硬化患者中这一比例为83%。 每种疾病的相对危险度通过条件多元Logistic回归计算。 虽然每天摄入酒精是肝硬化和慢性胰腺炎的主要危险因素，但吸烟仅与慢性胰腺炎的风险显著相关。 此外，吸烟者胰腺炎发病的平均年龄较低。
In a case control study alcohol intake and tobacco use were assessed between 1975 and 1987 in 103 male patients suffering from alcoholic cirrhosis of the liver, in 145 patients with chronic pancreatitis, and in 264 control subjects. The patients with chronic pancreatitis were significantly younger than the patients with cirrhosis (mean (SD) age 41.92 (2.4) epsilon 60.9 (11.6) years). Among the patients with chronic pancreatitis, 94% were both smokers and drinkers compared with 83% of patients with cirrhosis of the liver. The relative risks for each disease were calculated by conditional multiple logistic regression. Whereas daily intake of alcohol was a major risk factor for both cirrhosis of the liver and chronic pancreatitis, smoking was significantly related only to the risk of having chronic pancreatitis. Moreover, the mean age at onset of pancreatitis was lower among smokers.