CONDUCTION-VELOCITY AND CONDUCTION BLOCK AFTER EXPERIMENTAL ISCHEMIC NERVE INJURY
CONDUCTION-VELOCITY AND CONDUCTION BLOCK AFTER EXPERIMENTAL ISCHEMIC NERVE INJURY
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DOI：
10.1016/0022-510x(81)90007-1
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发表时间：
1981-01-01
影响因子：
4.4
通讯作者：
GILLIATT, RW
中科院分区：
文献类型：
--
作者：
FOWLER, CJ;GILLIATT, RW
本文观察了兔坐骨神经胫分支缺血性损伤对神经传导的影响。结扎髂总动脉和髂外动脉或髂内动脉和髂外动脉造成缺血性神经损伤40只。在手术后的时间间隔内检查运动纤维到足部小肌肉的传导，在大腿和脚踝处进行神经刺激。还研究了胫神经中的上行神经动作电位。在8只动物中，有广泛的有髓纤维变性的证据;肌肉动作电位不能被神经刺激激活，神经动作电位不存在。与此相反，有14只动物的动脉结扎似乎产生很少，如果有的话，神经变性;在这一组中，运动或传入速度没有显着变化。其余18只动物显示中度变化。虽然神经变性是广泛的，但它从未完全，在术后5-11天检查的9条神经中，可以在存活的纤维中证明大腿和踝关节之间的传导阻滞。其余9条神经存活纤维无阻滞，但最大运动速度明显减慢。在任何情况下，传导阻滞影响的运动纤维都不超过少数，其余的运动纤维都发生了完全变性。这与组织学表现一致，即与沃勒变性的数量相比，结旁和节段性脱髓鞘的数量相对较少。
The effect of ischemic nerve injury on conduction in the tibial branch of the sciatic nerve was studied in rabbits. Ischemic nerve damage was produced in 40 animals by ligation of the common and external or the internal and external iliacarteries. Conduction in the motor fibers to the small foot muscles was examined at intervals after operation, with nerve stimulation in the thigh and at the ankle. Ascending nerve action potentials in the tibial nerve were also studied. In 8 animals there was evidence of widespread degeneration of myelinated fibers; muscle action potentials could not be activated by nerve stimulation and nerve action potentials were absent. In contrast there were 14 animals in which arterial ligation appeared to produce little, if any, nerve degeneration; in this group there was no significant change in motor or afferent velocity. The remaining 18 animals showed changes of intermediate severity. While nerve degeneration was extensive, it was never complete, and in 9 nerves examined 5-11 days after surgery, conduction block between the thigh and ankle could be demonstrated in surviving fibers. In the other 9 nerves there was no block in surviving fibers but maximal motor velocity was significantly reduced. In no case did the conduction block affect more than a minority of the motor fibers, the remainder undergoing complete degeneration. This was in keeping with the histological appearances which showed a relatively small amount of paranodal and segmental demyelination compared with the amount of Wallerian degeneration.