Lost in Translation: The Gap in Scientific Advancements and Clinical Application.
Lost in Translation: The Gap in Scientific Advancements and Clinical Application.
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DOI：
10.3389/fbioe.2016.00043
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发表时间：
2016
影响因子：
5.7
通讯作者：
Fernandez-Moure JS
中科院分区：
文献类型：
--
作者：
Fernandez-Moure JS
医学和医疗技术的发展取决于基础科学研究从实验室到临床的成功转化。出于促进科学知识向患者转移的日益增长的需求，转化研究应运而生。在改善全球健康方面的重大飞跃，如抗生素、疫苗接种和癌症治疗，都在这一范式下取得了成功，但今天，实现这一理想情景变得越来越困难。随着医院收入需求的增加和财政支持的下降，临床医生保护的研究时间已经有限。同样，研究人员也被迫放弃耗费时间和资源的转化研究，专注于出版工作，以维持资金和专业发展。与科学创新和新科学领域的激增相比，设备开发和材料科学方面的变革性科学发现的实现明显滞后。在此，我们描述：当前的科学范式如何在新的卫生保健领域中挣扎;转化研究人员遇到的障碍;以及克服这些障碍的公共和私人解决方案。我们必须重新思考学术界的旧教条，重塑传统的研究途径，以便真正影响医疗竞技场，并最终影响最重要的人：病人。
The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. Out of the increasing need to facilitate the transfer of scientific knowledge to patients, translational research has emerged. Significant leaps in improving global health, such as antibiotics, vaccinations, and cancer therapies, have all seen successes under this paradigm, yet today, it has become increasingly difficult to realize this ideal scenario. As hospital revenue demand increases, and financial support declines, clinician-protected research time has been limited. Researchers, likewise, have been forced to abandon time- and resource-consuming translational research to focus on publication-generating work to maintain funding and professional advancement. Compared to the surge in scientific innovation and new fields of science, realization of transformational scientific findings in device development and materials sciences has significantly lagged behind. Herein, we describe: how the current scientific paradigm struggles in the new health-care landscape; the obstacles met by translational researchers; and solutions, both public and private, to overcoming those obstacles. We must rethink the old dogma of academia and reinvent the traditional pathways of research in order to truly impact the health-care arena and ultimately those that matter most: the patient.