Aldehyde-Associated Mutagenesis─Current State of Knowledge.
Aldehyde-Associated Mutagenesis─Current State of Knowledge.
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DOI：
10.1021/acs.chemrestox.3c00045
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发表时间：
2023-07-17
影响因子：
4.1
通讯作者：
Saini, Natalie
中科院分区：
文献类型：
--
作者：
Vijayraghavan, Sriram;Saini, Natalie
醛广泛存在于环境中，有多种来源，如食品和饮料，工业废水，香烟烟雾和添加剂。在许多研究中观察到接触几种醛的毒性作用。在分子水平上，醛类损伤DNA，交联DNA和蛋白质，导致脂质过氧化，并与包括癌症在内的疾病风险增加有关。有醛敏感性遗传倾向的人表现出严重的健康后果。在各种疾病中，如范可尼贫血和科凯恩综合征，去磷酸化代谢途径的丧失与DNA修复缺陷一起导致广泛的DNA损伤。重要的是，越来越多的研究正在探索与谷胱甘肽相关的致突变性，这可能为它们如何潜在地促进肿瘤发生提供关键见解。在这里，我们回顾了各种醛类的遗传毒性作用，特别是对DNA加合物的诱变性的环境衍生的醛。我们总结了醛和它们的主要DNA加合物的化学结构，讨论了各种方法，在体外和体内，通常用于测量与突变相关的突变，并强调了一些最近的研究与突变相关的签名和光谱。最后，我们的审查与讨论的挑战和未来的前景，调查与诱变。
Aldehydes are widespread in the environment, with multiple sources such as food and beverages, industrial effluents, cigarette smoke, and additives. The toxic effects of exposure to several aldehydes have been observed in numerous studies. At the molecular level, aldehydes damage DNA, cross-link DNA and proteins, lead to lipid peroxidation, and are associated with increased disease risk including cancer. People genetically predisposed to aldehyde sensitivity exhibit severe health outcomes. In various diseases such as Fanconi’s anemia and Cockayne syndrome, loss of aldehyde-metabolizing pathways in conjunction with defects in DNA repair leads to widespread DNA damage. Importantly, aldehyde-associated mutagenicity is being explored in a growing number of studies, which could offer key insights into how they potentially contribute to tumorigenesis. Here, we review the genotoxic effects of various aldehydes, focusing particularly on the DNA adducts underlying the mutagenicity of environmentally derived aldehydes. We summarize the chemical structures of the aldehydes and their predominant DNA adducts, discuss various methodologies, in vitro and in vivo, commonly used in measuring aldehyde-associated mutagenesis, and highlight some recent studies looking at aldehyde-associated mutation signatures and spectra. We conclude the Review with a discussion on the challenges and future perspectives of investigating aldehyde-associated mutagenesis.
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影响因子：
14.9
作者：
Dexheimer TS;Kozekova A;Rizzo CJ;Stone MP;Pommier Y
通讯作者：
Pommier Y
影响因子：
2.3
作者：
Brooks, PJ;Theruvathu, JA
通讯作者：
Theruvathu, JA
影响因子：
4.1
作者：
Cheng, G;Shi, YL;Hecht, SS
通讯作者：
Hecht, SS
影响因子：
15.8
作者：
Brooks PJ;Enoch MA;Goldman D;Li TK;Yokoyama A
通讯作者：
Yokoyama A
DOI：
10.1016/j.mrfmmm.2011.12.004
发表时间：
2012-03-01
影响因子：
2.3
作者：
Grogan, Dennis;Jinks-Robertson, Sue
通讯作者：
Jinks-Robertson, Sue