Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits.
Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits.
复制标题
清醒兔低血压出血期间阿片受体介导的肾神经活动减少。
DOI：
10.1161/01.res.63.1.165
复制
发表时间：
1988
影响因子：
20.1
通讯作者：
Vatner,SF
中科院分区：
文献类型：
--
作者：
Morita,H;Nishida,Y;Motochigawa,H;Uemura,N;Hosomi,H;Vatner,SF
在清醒的兔子中研究了出血对肾神经活动的影响以及随后用纳洛酮阻断阿片受体的影响。在 17 +/- 2 ml/kg 出血期间，平均动脉压保持恒定在 77 +/- 2 mm Hg，而肾神经活动增加了 159 +/- 16%。出血量为 25 +/- 1 ml/kg 后，平均动脉压下降 42 +/- 3 mm Hg，肾神经活动下降至出血前控制水平以下 41 +/- 15%。推注纳洛酮（3 mg/kg，静脉注射）使平均动脉压增加至 79 +/- 2 mm Hg，与出血前控制水平没有显着差异。肾神经活动增加了 171 +/- 28%，与非低血压性出血期间的峰值增加相当。另一天，再次出血，并在随后的低血压期间输注去氧肾上腺素。去氧肾上腺素使平均动脉压增加至出血前控制水平。随着平均动脉压的增加，肾神经活动从低血压出血期间的水平增加，并恢复到出血前的控制水平（-26+/-11%），但它没有恢复到非低血压出血期间达到的峰值。为了进一步检查纳洛酮对外源性阿片肽引起的平均动脉压和肾神经活动变化的阻断作用，在对照状态和纳洛酮治疗后均注射蛋氨酸脑啡肽。蛋氨酸脑啡肽（10微克/千克）的推注可降低平均动脉压（-8.1 +/- 2.0 mm Hg）和肾神经活动（-95 +/- 1%）。用纳洛酮 (0.5 mg/kg) 预处理可有效阻断这种抑制作用并减少肾神经活动。（摘要截断为 250 字）
Effects of hemorrhage on renal nerve activity and of subsequent opiate receptor blockade with naloxone were studied in conscious rabbits. Mean arterial pressure remained constant at 77 +/- 2 mm Hg through 17 +/- 2 ml/kg hemorrhage, while renal nerve activity increased by 159 +/- 16%. After 25 +/- 1 ml/kg hemorrhage, mean arterial pressure fell by 42 +/- 3 mm Hg, and renal nerve activity decreased below the prehemorrhagic control level by 41 +/- 15%. Bolus injection of naloxone (3 mg/kg i.v.) increased mean arterial pressure to 79 +/- 2 mm Hg, not significantly different from the prehemorrhagic control level. Renal nerve activity increased by 171 +/- 28%, comparable to the peak increase during nonhypotensive hemorrhage. On a different day, hemorrhage was repeated, and phenylephrine was infused during the subsequent hypotension. Phenylephrine increased mean arterial pressure to the prehemorrhagic control level. With increasing mean arterial pressure, renal nerve activity increased from its level during hypotensive hemorrhage and recovered toward the prehemorrhagic control level (-26 +/- 11%), but it did not return to the peak value reached during nonhypotensive hemorrhage. To further examine the blocking effects of naloxone on changes in mean arterial pressure and renal nerve activity induced by exogenous opiate peptides, methionine-enkephalin was injected both in the control state and after treatment with naloxone. A bolus injection of methionine-enkephalin (10 micrograms/kg) decreased mean arterial pressure (-8.1 +/- 2.0 mm Hg) and renal nerve activity (-95 +/- 1%). Pretreatment with naloxone (0.5 mg/kg) effectively blocked this depressor effect and reduction in renal nerve activity.(ABSTRACT TRUNCATED AT 250 WORDS)