Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5-a population-based study
Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5-a population-based study
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DOI：
10.1016/s1470-2045(13)70548-5
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发表时间：
2014-01-01
期刊：
影响因子：
51.1
通讯作者：
Peris-Bonet, Rafael
中科院分区：
文献类型：
--
作者：
Gatta, Gemma;Botta, Laura;Peris-Bonet, Rafael
欧洲儿童癌症的存活率和治愈率在过去40年里有了很大的提高，而且大部分都很好，尽管并非所有欧洲国家都是如此。EUROCARE-5生存研究估计了2000年至2007年间诊断为癌症的儿童的生存，评估了欧洲国家之间的生存差异是否发生了变化，并调查了1999年至2007年的变化。方法分析1978年1月1日至2007年12月31日诊断的157 499名儿童（0-14岁）的生存资料。他们来自29个国家74个基于人群的癌症登记处。我们计算了主要癌症和所有癌症的观察到的、国家加权的1年、3年和5年生存率。为了进行国家间的比较，我们使用校正组预后方法来提供经多个混杂因素（性别、年龄、诊断期，以及所有合并无中枢神经系统癌症的病例混合）校正后的生存概率。按地区和日历期计算年龄调整后的生存差异，并对所有癌症和主要癌症进行了周期分析。我们分析了59 579例病例。对于2000- 2007年诊断的所有儿童合并癌症，1年生存率为90.6% (95% CI 90.2-90.9)， 3年生存率为81.0% (95% CI 80.5-81.4)， 5年生存率为77.9% （95% CI 77.4-78.3）。所有癌症合并后的5年生存率从1999-2001年的76.1%（74.4-77.7）上升到2005-07年的79.1%(77.3-80.7)(风险比0.973,95% CI 0.965-0.982, p
Background Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007.Methods We analysed survival data for 157 499 children (age 0-14 years) diagnosed between Jan 1, 1978 and Dec 31, 2007. They came from 74 population-based cancer registries in 29 countries. We calculated observed, country-weighted 1-year, 3-year, and 5-year survival for major cancers and all cancers combined. For comparison between countries, we used the corrected group prognosis method to provide survival probabilities adjusted for multiple confounders (sex, age, period of diagnosis, and, for all cancers combined without CNS cancers, casemix). Age-adjusted survival differences by area and calendar period were calculated with period analysis and were given for all cancers combined and the major cancers.Findings We analysed 59 579 cases. For all cancers combined for children diagnosed in 2000-07, 1-year survival was 90.6% (95% CI 90.2-90.9), 3-year survival was 81.0 % (95% CI 80.5-81.4), and 5-year survival was 77.9% (95% CI 77.4-78.3). For all cancers combined, 5-year survival rose from 76.1% (74.4-77.7) for 1999-2001, to 79.1% (77.3-80.7) for 2005-07 (hazard ratio 0.973, 95% CI 0.965-0.982, p