Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China
Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China
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DOI：
10.1097/cej.0b013e3282f75f3e
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发表时间：
2008-10
影响因子：
2.4
通讯作者：
Xing-zheng Zheng;An-qiang Yang;X. Pan;Li-li Zheng;Xiao-ling Wang;Qiu-yuan Zhou;Xin-min Li;Li-hua Yan;B. Zhang;Hong-an Li;Jin-fang Jiang
中科院分区：
文献类型：
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作者：
Xing-zheng Zheng;An-qiang Yang;X. Pan;Li-li Zheng;Xiao-ling Wang;Qiu-yuan Zhou;Xin-min Li;Li-hua Yan;B. Zhang;Hong-an Li;Jin-fang Jiang
新疆维吾尔族妇女宫颈癌发病率较高（527/10万），且多在年轻时被诊断。我们支持这样的假设，即维吾尔族妇女可能携带不同的遗传因素，使他们更容易患CC比大多数汉族（中国）妇女生活在同一地区。本研究采用PCR-限制性片段长度多态性方法，比较维吾尔族和汉族妇女p53 Arg 72 Pro基因多态性与宫颈癌的关系。研究包括152例维吾尔族CC患者和110例对照，120例汉族CC患者和122例对照。在维吾尔族妇女中，CC与p5372 Arg/Arg纯合性（χ2=7.196，P<0.05）和HPV-16（χ2=7.177，P<0.05）有关。汉族妇女CC与p5372 Pro/Pro纯合性相关（χ2=8.231，P<0.05）。这些观察结果表明，具有不同遗传背景的个体对CC具有不同的易感性，至少在中国研究的维吾尔族和汉族妇女中是如此。
Minority Uigur women residing in Xinjiang, in the northwest of China, have a high incidence of cervical carcinoma (CC; 527/100 000) and are often diagnosed young. We favor the hypothesis that Uigur women may carry different genetic factor(s) making them more susceptible to CC than majority Han (Chinese) women living in the same region. Using PCR-restriction fragment length polymorphism, we investigated associations of a p53Arg72Pro polymorphism with CC in Uigur women compared with those in Han women. The study included 152 Uigur patients with CC and 110 controls, and 120 Han patients with CC and 122 controls. In Uigur women, CC was associated with p5372Arg/Arg homozygosity (χ2=7.196, P<0.05) and with human papillomavirus-16 (χ2=7.177, P<0.05). In Han women, however, CC was associated with p5372Pro/Pro homozygosity (χ2=8.231, P<0.05). These observations suggest that individuals with different genetic backgrounds carry different susceptibilities to CC, at least in the Uigur and Han ethnic women studied in China.