Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer.
Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer.
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DOI：
10.3390/ijms19020431
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发表时间：
2018-02-01
影响因子：
5.6
通讯作者：
Melisi D
中科院分区：
文献类型：
--
作者：
Carbone C;Piro G;Merz V;Simionato F;Santoro R;Zecchetto C;Tortora G;Melisi D
肿瘤细胞或肿瘤微环境细胞分泌因子表达的改变是肿瘤发生发展的关键事件。在过去的十年中，新的证据支持血管生成素样蛋白家族成员的自分泌和旁分泌在血管生成、炎症以及在肿瘤发生和转移发展的不同阶段的调节中的作用。因此，ANGPTL蛋白无论是作为预测预后的生物标志物，还是作为癌症治疗的新靶点，都变得很有吸引力。在这里，我们概述了ANGPTL蛋白在血管生成、肿瘤进展和转移中的功能。此外，我们还讨论了支持它们作为癌症治疗预后或预测生物标记物作用的最新证据。虽然ANGPTL蛋白在癌症中的作用尚未完全阐明，但越来越多的证据表明，它们在癌细胞的增殖和侵袭特性中起关键作用。此外，鉴于ANGPTL蛋白在几种侵袭性实体肿瘤中普遍过表达，以及它们在肿瘤细胞和肿瘤微环境中的作用，ANGPTL蛋白网络的研究领域可能为未来治疗策略的发展提供新的潜在靶点。
Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last decade, emerging evidences supported the autocrine and paracrine activity of the members of the Angiopoietin-like (ANGPTL) protein family in angiogenesis, inflammation and in the regulation of different steps of carcinogenesis and metastasis development. Thus, ANGPTL proteins become attractive either as prognostic or predictive biomarkers, or as novel target for cancer treatment. Here, we outline the current knowledge about the functions of the ANGPTL proteins in angiogenesis, cancer progression and metastasis. Moreover, we discuss the most recent evidences sustaining their role as prognostic or predictive biomarkers for cancer therapy. Although the role of ANGPTL proteins in cancer has not been fully elucidated, increasing evidence suggest their key effects in the proliferative and invasive properties of cancer cells. Moreover, given the common overexpression of ANGPTL proteins in several aggressive solid tumors, and their role in tumor cells and cells of the tumor microenvironment, the field of research about ANGPTL proteins network may highlight new potential targets for the development of future therapeutic strategies.
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DOI：
10.1158/1078-0432.ccr-11-1185
发表时间：
2011-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Carbone C;Moccia T;Zhu C;Paradiso G;Budillon A;Chiao PJ;Abbruzzese JL;Melisi D
通讯作者：
Melisi D
影响因子：
20.1
作者：
Cazes, Aurelie;Galaup, Ariane;Monnot, Catherine
通讯作者：
Monnot, Catherine
影响因子：
13.5
作者：
Chen, Hsin-An;Kuo, Tsang-Chih;Su, Jen-Liang
通讯作者：
Su, Jen-Liang
影响因子：
3.9
作者：
Cui, J. G.;Zhao, Y.;Lukiw, W. J.
通讯作者：
Lukiw, W. J.
影响因子：
3.7
作者：
Cox AR;Barrandon O;Cai EP;Rios JS;Chavez J;Bonnyman CW;Lam CJ;Yi P;Melton DA;Kushner JA
通讯作者：
Kushner JA