REGENERATION OF SENSORY HAIR-CELLS AFTER ACOUSTIC TRAUMA
REGENERATION OF SENSORY HAIR-CELLS AFTER ACOUSTIC TRAUMA
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DOI：
10.1126/science.3381100
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发表时间：
1988-06-24
期刊：
影响因子：
56.9
通讯作者：
COTANCHE, DA
中科院分区：
文献类型：
--
作者：
CORWIN, JT;COTANCHE, DA
耳蜗毛细胞的任何丢失都被推定为导致永久性听力障碍，因为这些细胞的产生通常在出生前就停止了。然而，在声创伤后，鸡成熟耳蜗中受损的感觉细胞被替换。新的细胞似乎是由支持细胞有丝分裂产生的，这些支持细胞在损伤部位存活，在没有创伤的情况下不分裂。这种创伤诱导的正常运动后细胞分裂可能会导致严重听力损失的恢复。
Any loss of cochlear hair cells has been presumed to result in a permanent hearing deficit because the production of these cells normally ceases before birth. However, after acoustic trauma, injured sensory cells in the mature cochlea of the chicken are replaced. New cells appear to be produced by mitosis of supporting cells that survive at the lesion site and do not divide in the absence of trauma. This trauma-induced division of normally postmotitic cells may lead to recovery from profound hearing loss.