Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats
Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats
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DOI：
10.1016/j.fct.2008.07.003
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发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Jang, Dong Deuk
中科院分区：
文献类型：
--
作者：
Cho, Wan-Seob;Han, Beorn Seok;Jang, Dong Deuk
3-一氯丙烷- 1,2-二醇（α-氯代醇，3-MCPD）是一种众所周知的污染物，已在多种食品和成分中检测到，并且也被怀疑是致癌的原因。在本研究中，研究了 3-MCPD 对 SD 大鼠的致癌性。 50 只雄性和 50 只雌性大鼠组暴露于含有 0、25、100 或 400 ppm 3-MCPD 的饮用水两年。给予400 ppm 3-MCPD的雄性和雌性大鼠的体重和水消耗量显着低于对照组。雄性大鼠肾小管腺瘤或肾癌、间质细胞瘤的发生率均呈与剂量相关的正向趋势。给予 400 ppm 3-MCPD 的雄性大鼠肾小管癌和 Leydig 细胞瘤的发病率显着增加。雌性大鼠肾小管腺瘤的发生率呈正趋势，其中400 ppm 3-MCPD组显着。总之，基于肾小管癌和间质细胞瘤发病率的增加，有明确的证据表明 3-MCPD 对雄性 SD 大鼠具有致癌活性。基于肾小管腺瘤发病率的增加，有一些证据表明 3-MCPD 对雌性 SD 大鼠具有致癌活性。 (C) 2008 Elsevier Ltd. 保留所有权利。
3-Monochloropropane- 1,2-diol (alpha-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a Suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred With dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas. (C) 2008 Elsevier Ltd. All rights reserved.