A nested case-control study of stomach cancer in relation to green tea consumption in Japan
A nested case-control study of stomach cancer in relation to green tea consumption in Japan
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DOI：
10.1038/sj.bjc.6601512
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发表时间：
2004-01-01
影响因子：
8.8
通讯作者：
Yoshimura, T
中科院分区：
文献类型：
--
作者：
Hoshiyama, Y;Kawaguchi, T;Yoshimura, T
为了评估饮用绿色茶是否能预防胃癌，由日本厚生省赞助的日本癌症风险评估合作研究（JACC研究）计算了相对风险（RR）。该研究基于157例发病病例和285例年龄在40-79岁的对照。考克斯比例风险回归分析用于估计胃癌的RR。结果发现，饮用绿色茶对胃癌没有保护作用。在调整年龄、吸烟状况后，H.幽门螺杆菌感染史、消化性溃疡史、胃癌家族史沿着某些饮食因素，每天喝一到两杯、三到四杯、五到九杯、十杯或更多的绿色茶，相对于每天喝不到一杯的人，其风险为1.3（95%置信区间（CI）：0.6-2.8）、1.0（95% CI：0.5-1.9）、0.8（95% CI：0.4-1.6）和1.2（95% CI：0.6-2.5）（趋势P =0.899）。我们没有发现绿色茶消费和胃癌风险之间的负相关。
To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40-79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (CI): 0.6-2.8), 1.0 (95% CI: 0.5-1.9), 0.8 (95% CI: 0.4-1.6), and 1.2 (95% CI: 0.6-2.5), respectively (P for trend=0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.