Targeting Breast Cancer Cells and Their Metastases Through Luteinizing Hormone Releasing Hormone (LHRH) Receptors Using Magnetic Nanoparticles
Targeting Breast Cancer Cells and Their Metastases Through Luteinizing Hormone Releasing Hormone (LHRH) Receptors Using Magnetic Nanoparticles
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DOI：
10.1166/jbn.2005.027
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发表时间：
2005-06-01
影响因子：
2.9
通讯作者：
Hormes, Josef
中科院分区：
文献类型：
--
作者：
Leuschner, Carola;Kumar, Challa S. S. R.;Hormes, Josef
人乳腺癌异种移植瘤的原发肿瘤和转移瘤是由黄体生成素释放激素(LHRH)与超顺磁性氧化铁纳米颗粒(SPION)结合并整合到细胞中而特异性靶向的。在体外，LHRH结合的磁性纳米颗粒累积的浓度是单独磁性颗粒的12倍。在体内，乳腺到肺转移瘤中LHRH-Spion的积聚浓度取决于转移细胞的数量，而未结合的颗粒不会在肺转移瘤中积聚。
Primary tumors and metastases from human breast cancer xenografts are specifically targeted by luteinizing hormone releasing hormone (LHRH) conjugated to superparamagnetic iron oxide nanoparticles (SPION) and incorporated into the cells. In vitro LHRH-bound magnetic nanoparticles accumulated in a 12-fold higher concentration than magnetite particles alone. In vivo, breast to lung metastases accumulated LHRH-SPION at concentrations dependent on the number of metastatic cells, while unconjugated particles did not accumulate in lung metastases.