Deoxynivalenol: a trigger for intestinal integrity breakdown
Deoxynivalenol: a trigger for intestinal integrity breakdown
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DOI：
10.1096/fj.13-238717
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发表时间：
2014-06-01
期刊：
影响因子：
4.8
通讯作者：
Fink-Gremmels, Johanna
中科院分区：
文献类型：
--
作者：
Akbari, Peyman;Braber, Saskia;Fink-Gremmels, Johanna
结肠上皮屏障的解体被认为是炎症性肠病和乳糜泻发生和发展的关键事件。由于这些疾病的主要病因尚不清楚，我们假设，在以谷物为基础的人类饮食中发现的真菌代谢产物-使用水平阻抗测量，我们证明了DON分解人Caco-2细胞单层，
Disintegration of the colonic epithelial barrier is considered a key event in the initiation and progression of inflammatory bowel and celiac disease. As the primary etiology of these diseases remains unknown, we hypothesized that the trichothecene deoxynivalenol (DON), a fungal metabolite found in grain-based human diets, might be one of the triggers resulting in an impairment of the intestinal tight junction network preceding an inflammatory response. Using horizontal impedance measurements, we demonstrate that DON disintegrates a human Caco-2 cell monolayer within