High-dose riboflavin treatment is efficacious in migraine prophylaxis:: an open study in a tertiary care centre
High-dose riboflavin treatment is efficacious in migraine prophylaxis:: an open study in a tertiary care centre
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DOI：
10.1111/j.1468-1331.2004.00813.x
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Arnold, G
中科院分区：
文献类型：
--
作者：
Boehnke, C;Reuter, U;Arnold, G
本研究的目的是探讨核黄素预防偏头痛的疗效。在一家专科门诊进行了一项开放标签研究。患者每天接受400 mg核黄素胶囊。记录治疗前、治疗后3个月和6个月头痛的频率、持续时间、强度和流产药物的使用情况。头痛次数由治疗前的4天/月减少到治疗3个月和6个月后的2天/月（P < 0.05）。治疗3个月和6个月后，流产药物的使用从7单位/月下降到4.5单位/月（P < 0.05）。相比之下，头痛时间和头痛强度没有显着变化。我们可以证明核黄素治疗后头痛频率显著降低。此外，流产的抗偏头痛片剂的数量也有所减少。与以前的研究结果一致，我们的研究结果表明，核黄素是一种安全和耐受性良好的偏头痛预防替代品。
The aim of this study was to investigate the efficacy of riboflavin for the prevention of migraine. An open label study was performed in a specialized outpatient clinic. Patients received 400 mg riboflavin capsules per day. Headache frequency, duration, intensity and the use of abortive drugs were recorded at baseline and 3 and 6 months after treatment. Headache frequency was significantly reduced from 4 days/month at baseline to 2 days/month after 3 and 6 months (P < 0.05). The use of abortive drugs decreased from 7 units/month to 4.5 units/month after 3 and 6 months of treatment (P < 0.05). In contrast, headache hours and headache intensity did not change significantly. We could demonstrate a significant reduction of headache frequency following riboflavin treatment. In addition, the number of abortive anti-migraine tablets was reduced. In line with previous studies our findings show that riboflavin is a safe and well-tolerated alternative in migraine prophylaxis.