Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran
Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran
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DOI：
10.1007/s40519-020-00851-5
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发表时间：
2020-02-04
影响因子：
2.9
通讯作者：
Bonyadi, Morteza
中科院分区：
文献类型：
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作者：
Aliasghari, Fereshteh;Nazm, Saba A.;Bonyadi, Morteza
美味食物带来的愉悦感会刺激享乐性饮食，因此，这可能是肥胖的罪魁祸首。多巴胺受体多态性，尤其是调节D2受体的基因变异，包括ANKK1和DRD2，是评估享乐性饮食个体差异的主要候选者。本研究旨在探讨T （rs1800497）和Del （rs1799732）等位基因与伊朗阿塞拜疆女性体重指数（BMI）和享乐性饥饿之间的可能关联。方法采用PCR-RFLP方法对372例体重超重/肥胖（BMI = 25 kg/m(2)）和159例体重正常（BMI 18.5 ~ 24.9 kg/m(2)）的人群进行ANNK1和DRD2基因多态性分型。BMI和享乐饥饿也被评估。结果ANNK1基因CC型363人（68.36%），CT型152人（28.63%），TT型16人（3.01%）。在515份DRD2基因分型样本中，Ins/Ins、Ins/Del和Del/Del基因型分别为315份（60.51%）、173份（33.59%）和27份（5.24%）。基因型和基因型频率组间差异有统计学意义（p = 0.04）。T+基因型（TT + TC）和T-基因型（CC）在BMI和享乐饥饿评分上差异有统计学意义（p < 0.05）。此外，Del+组（Del/Del + Ins/Del）的BMI和享乐饥饿评分高于Del-组（Ins/Ins） （p < 0.05）。结论超重/肥胖人群中T和Del等位基因频率较高。ANKK1基因多态性（rs1800497）和DRD2基因多态性（rs1799732）与BMI和享乐饥饿有显著相关性。
Background Pleasure from palatable foods can stimulate hedonic eating and, therefore, might be a major culprit for obesity. Dopamine receptor polymorphisms, especially variants in the genes regulating the D2 receptor, including ANKK1 and DRD2, are the prime candidates for assessing the individual differences in hedonic eating. This study was carried out to investigate the possible associations of the T (rs1800497) and Del (rs1799732) alleles with body mass index (BMI) and hedonic hunger among Iranian Azeri women. Methods A total of 372 healthy overweight/obese subjects (BMI >= 25 kg/m(2)) and 159 normal weight individuals (BMI 18.5-24.9 kg/m(2)) were genotyped for the polymorphisms of ANNK1 and DRD2 genes using PCR-RFLP. BMI and hedonic hunger were also evaluated. Results Three hundred and sixty-three (68.36%), 152 (28.63%), and 16 (3.01%) of the participants had CC, CT, and TT genotypes for ANNK1 gene, respectively. Of 515 samples genotyped for DRD2 gene, 315 (60.51%), 173 (33.59%), and 27 (5.24%) had Ins/Ins, Ins/Del, and Del/Del genotypes, respectively. The genotype and genotype frequencies were significantly different between the groups (p = 0.04). Significant differences were observed between the T+ genotype (TT + TC) and the T- genotype (CC) regarding the BMI and hedonic hunger scores (p < 0.05). In addition, Del+ group (Del/Del + Ins/Del) had higher BMI and hedonic hunger scores compared to Del- group (Ins/Ins) (p < 0.05). Conclusions Our findings showed that the frequencies of T and Del alleles were greater in the overweight/obese individuals. Also, the polymorphism of ANKK1 (rs1800497) and polymorphism of the DRD2 gene (rs1799732) showed significant associations with BMI and hedonic hunger.