Role of T Lymphocytes in the Pathogenesis of Chlamydia Disease
Role of T Lymphocytes in the Pathogenesis of Chlamydia Disease
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DOI：
10.1086/605411
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发表时间：
2009-09-15
影响因子：
6.4
通讯作者：
Black, Carolyn M.
中科院分区：
文献类型：
--
作者：
Igietseme, Joseph U.;He, Qing;Black, Carolyn M.
预防沙眼衣原体的眼部生殖疾病需要疫苗。受感染的宿主产生了免疫，尽管是暂时的，实验性疫苗在动物模型中产生了显著的保护性免疫，从而推动了疫苗的开发。由于感染会引起后遗症，感染和疫苗诱导免疫之间的功能关系尚不清楚。我们假设感染和疫苗诱导的免疫在功能上是不同的，特别是在预防后遗症的能力上。对衣原体免疫的小鼠，通过以前的感染或疫苗接种产生免疫力，表现出显著程度的保护性免疫，其特征是感染强度较低，病程较短。然而，接种疫苗的小鼠可以避免不育，而感染前的小鼠则没有。因此，感染诱导免疫不能阻止导致不孕的病理过程。此外，T细胞亚群，特别是CD8 T细胞，在衣原体诱导的不孕中起主要作用。该结果对衣原体病的免疫发病机制和新疫苗策略具有重要意义。
Vaccines are needed to prevent the oculogenital diseases of Chlamydia trachomatis. Infected hosts develop immunity, although temporary, and experimental vaccines have yielded significant protective immunity in animal models, fueling the impetus for a vaccine. Because infections cause sequelae, the functional relationship between infection- and vaccine-induced immunity is unclear. We hypothesized that infection- and vaccine-induced immunity are functionally distinct, particularly in the ability to prevent sequelae. Chlamydia-immune mice, with immunity generated by either a previous infection or vaccination, exhibited a significant degree of protective immunity, marked by a lower-intensity, abbreviated course of infection. However, vaccinated mice were protected from infertility, whereas preinfected mice were not. Thus, infection- induced immunity does not prevent the pathologic process leading to infertility. Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies.