Comparison of adrenocortical zonation in C57BL/6J and DDD mice.
Comparison of adrenocortical zonation in C57BL/6J and DDD mice.
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C57BL/6J 和 DDD 小鼠肾上腺皮质分区的比较。
DOI：
10.1538/expanim.44.285
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发表时间：
1995
影响因子：
2.4
通讯作者：
A. Matsuzawa
中科院分区：
文献类型：
--
作者：
S. Tanaka;A. Matsuzawa
比较了两个来源和遗传背景不同的近交系小鼠C57BL/6J和DDD的肾上腺重量和肾上腺皮质带的分布。在肾上腺重量和束状带、网状带和X带的形态上存在明显的品系和性别差异。无论性别，DDD肾上腺均大于C57BL/6J肾上腺。雌性DDD小鼠的束状纹状体厚度大于雄性。DDD雄性在70日龄时出现结节，随后随着年龄的增长而增大，而C57BL/6J雄性则没有结节。怀孕、怀孕和哺乳的临产女性也出现了类似的结节，但处女没有。X区变性男性早于女性。雄性在5周龄前该带消失，但DDD处女的厚度随着年龄的增长而逐渐减少。DDD的雌性X带较厚，有空泡化，而C57BL/6J的雌性X带较薄，无空泡化。网状纹状体和X带内皮层的明显菌株差异表明，它们的形态可能主要受遗传学调节，并受到内分泌学的影响。
Adrenal weights and adrenocortical zonation were compared in two inbred mouse strains, C57BL/6J and DDD, which are different in both origin and genetic background. Clear strain and sex differences were observed in the adrenal weight and the morphology of the zona fasciculata, z. reticularis and X zone. DDD adrenals were larger than C57BL/6J ones regardless of sex. The z. fasciculata was thicker in female than male DDD mice. The z. reticularis of DDD males developed nodules at 70 days of age, followed by an increase in size with age, while that of C57BL/6J males did not. Parous females experiencing pregnancy, gestation and lactation also developed similar nodules, but virgins did not. The X zone degeneration occurred earlier in males than in females. This zone disappeared before 5 weeks of age in males but gradually decreased in thickness with age in DDD virgins. The female X zone was thicker and degenerated with vacuolation in DDD, while it was thinner and degenerated without vacuolation in C57BL/6J. Such clear strain differences in the inner cortices, z. reticularis and X zone, suggested that their morphology might be regulated primarily by genetics and modified by endocrinology.