ENHANCEMENT OF ANTIGEN-INDUCED T-CELL PROLIFERATION BY SOLUBLE CD26 DIPEPTIDYL PEPTIDASE-IV
ENHANCEMENT OF ANTIGEN-INDUCED T-CELL PROLIFERATION BY SOLUBLE CD26 DIPEPTIDYL PEPTIDASE-IV
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DOI：
10.1073/pnas.91.8.3082
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发表时间：
1994-04-12
影响因子：
11.1
通讯作者：
MORIMOTO, C
中科院分区：
文献类型：
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作者：
TANAKA, T;DUKECOHAN, JS;MORIMOTO, C
添加可溶性重组CD26 (sCD26)可增强由回忆抗原破伤风类毒素诱导的外周血淋巴细胞的增殖。 sCD26本身不提供促有丝分裂信号，并且不会增强T细胞对其他促有丝分裂刺激物（例如植物血凝素和抗CD3）的增殖反应。二肽基肽酶IV阴性的sCD26没有这种增强作用，这意味着需要酶活性。研究发现体内人血浆sCD26/二肽基肽酶IV水平存在较大变化，可能调节T细胞活性。血浆 sCD26 水平较高且对破伤风类毒素刺激反应强烈的个体的外周血淋巴细胞对外源添加的 sCD26 的增强作用不敏感。这表明血浆sCD26在体内调节了这些个体的T细胞的反应性，并且内源性血浆sCD26通过允许抗原特异性T细胞对其特定抗原发挥最大反应来调节免疫反应。
The addition of a soluble recombinant CD26 (sCD26) enhanced proliferation of peripheral blood lymphocytes induced by the recall antigen tetanus toxoid. sCD26 itself did not provide a mitogenic signal and did not augment the proliferative response of T cells to other mitogenic stimuli such as phytohemagglutinin and anti-CD3. Dipeptidyl peptidase IV-negative sCD26 did not have this enhancement effect, implying a requirement for enzyme activity. It was found that there exists a large variation in the levels of human plasma sCD26/dipeptidyl peptidase IV in vivo which may regulate T-cell activity. Peripheral blood lymphocytes from individuals whose plasma sCD26 was high and responded strongly to tetanus toxoid stimulation were insensitive to the enhancing effects of exogenously added sCD26. This suggests that plasma sCD26 had modulated the responsiveness of T cells of these individuals in vivo and that the endogenous plasma sCD26 regulates immune responses by allowing antigen-specific T cells to exert a maximal response to their specific antigen.