PROGNOSTIC VALUE OF CA-19.9 LEVELS IN COLORECTAL-CANCER
PROGNOSTIC VALUE OF CA-19.9 LEVELS IN COLORECTAL-CANCER
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DOI：
10.1097/00000658-199207000-00008
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发表时间：
1992-07-01
影响因子：
9
通讯作者：
BALLESTA, AM
中科院分区：
文献类型：
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作者：
FILELLA, X;MOLINA, R;BALLESTA, AM
测定293例结直肠癌患者血清碳水化合物抗原19.9 （CA 19.9）和癌胚抗原水平。35%的患者碳水化合物抗原19.9高于37 U/mL的临界值。糖类抗原19.9敏感性与肿瘤分期有关。61%的患者癌胚抗原高于3.5 ng/mL的临界值，同时使用两种标志物可使敏感性提高至66%。CA 19.9预处理水平在局部肿瘤中的主要应用是预后。碳水化合物抗原19.9比常规分期方法提供了更多的预后信息。在Dukes' C肿瘤患者中，获得了将这些患者分配到复发风险低或高组的额外信息。癌胚抗原的预后意义与Dukes分类无关。
Pretreatment serum levels of carbohydrate antigen 19.9 (CA 19.9) and carcinoembryonic antigen were measured in 293 patients with colorectal cancer. Carbohydrate antigen 19.9 was above the cut-off limit of 37 U/mL in 35% of patients. Carbohydrate antigen 19.9 sensitivity was related to tumor stage. Carcinoembryonic antigen was above the cut-off level of 3.5 ng/mL in 61% of patients, and the simultaneous use of two markers increased sensitivity to 66%. The main use of pretreatment levels of CA 19.9 in locoregional cancer is in prognosis. Carbohydrate antigen 19.9 provided more prognostic information than that obtained by conventional staging methods. In patients with Dukes' C tumors, additional information was obtained for allocation of these patients into groups at low or high risk of recurrence. Prognostic significance of carcinoembryonic antigen was not independent of Dukes' classification.