Alcohol consumption and HIV disease progression
Alcohol consumption and HIV disease progression
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DOI：
10.1097/qai.0b013e318142aabb
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Saitz, Richard
中科院分区：
文献类型：
--
作者：
Samet, Jeffrey H.;Cheng, Debbie M.;Saitz, Richard
目的：评估饮酒量与 HIV 疾病进展实验室标志物之间的关系。方法：我们前瞻性评估了 1997 年至 2003 年间招募的 595 名有酗酒问题的 HIV 感染者长达 7 年的 CD4 细胞计数、HIV RNA 水平和饮酒量。我们使用控制已知预后因素（包括依从性和抑郁症状）的纵向回归模型研究了这些 HIV 疾病进展标志物与饮酒量的关系，并通过抗逆转录病毒治疗进行分层结果：在未接受 ART 的受试者中，大量饮酒与较低的 CD4 细胞计数相关（与戒酒相比，调整后平均减少 48.6 个细胞/μL；P = 0.03），但与较高的 log(10) HIV RNA 无关。在接受 ART 的受试者中，大量饮酒与较低的 CD4 细胞计数或较高的 HIV RNA 对数无关。结论：大量饮酒对未接受 ART 的 HIV 感染者的 CD4 细胞计数有负面影响。除了已知的酒精对 ART 依从性的有害影响外，这些研究结果表明，未接受 ART 的患者避免大量饮酒可能对 HIV 疾病进展产生有益影响。
Objective: To assess the relation between alcohol consumption and laboratory markers of HIV disease progression.Methods: We prospectively assessed CD4 cell counts, HIV RNA levels, and alcohol consumption for up to 7 years in 595 HIV infected persons with alcohol problems recruited between 1997 and 2003. We investigated the relation of these markers of HIV disease progression to alcohol consumption using longitudinal regression models controlling for known prognostic factors, including adherence and depressive symptoms, and stratified by antiretroviral therapy (ART) use.Results: Among subjects who were not on ART, heavy alcohol consumption was associated with a lower CD4 cell count (adjusted mean decrease of 48.6 cells/mu L compared with abstinence; P = 0.03) but not with higher log(10) HIV RNA. Among subjects who were on ART, heavy alcohol consumption was not associated with a lower CD4 cell count or higher log,a HIV RNA.Conclusions: Heavy alcohol consumption has a negative impact on the CD4 cell count in HIV infected persons not receiving ART. In addition to the known deleterious effects of alcohol on ART adherence, these findings suggest that avoiding heavy alcohol consumption in patients not on ART may have a beneficial effect on HIV disease progression.