Natural tissue microenvironmental conditions modulate adhesive material performance.
Natural tissue microenvironmental conditions modulate adhesive material performance.
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DOI：
10.1021/la303155p
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发表时间：
2012-10-30
期刊：
影响因子：
--
通讯作者：
Artzi N
中科院分区：
文献类型：
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作者：
Oliva N;Shitreet S;Abraham E;Stanley B;Edelman ER;Artzi N
我们通过匹配材料和组织特性来设计和优化组织响应性粘合材料。一种基于葡聚糖醛和树枝状大分子胺的双组分材料，通过醛-胺交联提供粘性凝胶，并通过与组织胺的葡聚糖醛选择性反应产生粘附性界面。通过改变乙醛-胺化学，我们研究了组织表面的变化(十二指肠、空肠和回肠中的浆液胺密度)如何影响与不同组成(醛含量)的粘连材料的相互作用。有趣的是，由于肠道组织胺密度的不同，相同的粘合剂配方与小肠的三个区域发生不同的反应，影响组织-材料界面的形态、粘合强度和粘合机械性能。虽然组织提供了与材料相互作用的化学锚，但我们能够通过改变粘合剂配方，使用旨在控制醛/胺比例的灵活变量的双组分材料，来调节小肠组织每一部分的粘合强度。这种针对组织的方法应该应用于广泛的生物材料，在材料设计中考虑到特定的微环境条件。
We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive interface created by a dextran aldehyde-selective reaction with tissue amines. By altering aldehyde–amine chemistry, we examined how variations in tissue surfaces (serosal amine density in the duodenum, jejunum, and ileum) affect interactions with adhesive materials of varied compositions (aldehyde content). Interestingly, the same adhesive formulation reacts differentially with the three regions of the small intestine as a result of variation in the tissue amine density along the intestinal tract, affecting the tissue–material interfacial morphology, adhesion strength, and adhesive mechanical properties. Whereas tissues provide chemical anchors for interaction with materials, we were able to tune the adhesion strength for each section of the small intestine tissue by altering the adhesive formulation using a two-component material with flexible variables aimed at controlling the aldehyde/amine ratio. This tissue-specific approach should be applied to the broad spectrum of biomaterials, taking into account specific microenvironmental conditions in material design.