Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium
Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium
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DOI：
10.1093/annonc/mdr562
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发表时间：
2012-07-01
影响因子：
50.5
通讯作者：
Potter, J. D.
中科院分区：
文献类型：
--
作者：
Boffetta, P.;Hazelton, W. D.;Potter, J. D.
吸烟、饮酒和体重指数（BMI）在小肠癌病因学中的作用的证据主要基于来自欧洲和美国的病例对照研究。我们协调了来自中国大陆、日本、韩国、新加坡和台湾的12项队列研究的数据，包括超过50万例受试者，平均随访10.6年。我们计算了BMI和（仅男性）吸烟和饮酒的风险比（HR）。共观察到134例事件病例（49例腺癌，11例类癌，46例其他组织学类型，28例组织学未知）。高BMI受试者的HR增加趋势无统计学意义[BMI > 27.5 kg/m2的HR为22.6-25.0，1.50; 95%置信区间（CI）为0.76-2.96]。研究结果表明，吸烟与此无关联;与不吸烟者相比，每周饮酒> 400 g乙醇的男性的HR为1.57（95% CI 0.66-3.70）。饮酒的病因作用提出。我们的研究结果加强了现有的证据，即小肠癌的流行病学类似于结直肠癌。
The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States.We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking.A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI > 27.5 kg/m(2), compared with 22.6-25.0, 1.50; 95% confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking > 400 g of ethanol per week had an HR of 1.57 (95% CI 0.66-3.70), compared with abstainers.Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.