Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia
Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia
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DOI：
10.1016/j.amjmed.2004.06.032
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发表时间：
2004-11-15
影响因子：
5.9
通讯作者：
Lazzarino, M
中科院分区：
文献类型：
--
作者：
Passamonti, F;Rumi, E;Lazzarino, M
目得：评估真性红细胞增多症和原发性thrombocytemia.METHODS患者生存期的预期寿命和预后因素：研究样本包括831例真性红细胞增多症（n = 396; 4184人年随访）或原发性血小板增多症（n = 435; 4304人年随访）。每组的死亡率进行了比较与意大利人口使用标准化死亡率比（SMR）的基础上获得的预期寿命数据从意大利研究所的Statistics.RESULTS：15年的生存率为65%的红细胞增多症患者和73%的血小板增多症。通过考克斯回归分析，死亡的独立预测因素是红细胞增多症（风险比[HR] = 2.2; P = 0.0002）和血小板增多症（HR = 2; P = 0.01）的血栓形成史，以及血小板增多症的男性（HR = 1.8; P = 0.03）。与一般人群相比，死亡率高1.6倍（P
PURPOSE: To assess life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia.METHODS: The study sample consisted of 831 consecutive patients with polycythemia vera (n = 396; 4184 person-years of follow-up) or essential thrombocythemia (n = 435; 4304 person-years of follow-up). Mortality in each group was compared with the Italian population using the standardized mortality ratio (SMR) based on life expectancy data obtained from the Italian Institute of Statistics.RESULTS: The 15-year survival was 65% in patients with polycythemia and 73% in those with thrombocythemia. By Cox regression analysis, the independent predictors of death were a history of thrombosis for polycythemia (hazard ratio [HR] = 2.2; P = 0.0002) and thrombocythemia (HR = 2; P = 0.01), and male sex (HR = 1.8; P = 0.03) for thrombocythemia. Mortality compared with the general population was 1.6-fold higher (P