Respiratory syncytial virus infection
Respiratory syncytial virus infection
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DOI：
10.1016/s0140-6736(99)80040-3
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发表时间：
1999-09-04
期刊：
影响因子：
168.9
通讯作者：
Simoes, EAF
中科院分区：
文献类型：
--
作者：
Simoes, EAF
呼吸道合胞病毒（RSV），长期以来被认为是婴儿下呼吸道的主要病毒病原体，也与成人，特别是老年人的严重肺部疾病有关。这一事实，以及用RSV的多克隆或单克隆抗体进行被动预防可预防高危婴儿和儿童的严重肺部疾病的证明，重新引起了人们对保护周围免疫机制和疫苗开发的兴趣。
Respiratory syncytial virus (RSV), long recognised as the major viral pathogen of the lower respiratory tract of infants, has also been implicated in severe lung disease in adults, especially the elderly. This fact, and the demonstration that passive prophylaxis with either polyclonal or monoclonal antibody to RSV prevents severe lung disease in high-risk infants and children, has led to renewed interest in the immune mechanisms surrounding protection, and the development of vaccines.