Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues.
Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues.
复制标题
DOI：
10.3389/fcell.2017.00022
复制
发表时间：
2017
影响因子：
5.5
通讯作者：
Fournier-Thibault C
中科院分区：
文献类型：
--
作者：
Nassari S;Duprez D;Fournier-Thibault C
骨骼肌属于肌肉骨骼系统，由骨骼、肌腱、韧带和不规则结缔组织组成，与运动神经和血管关系密切。调节肌发生的内在分子信号已被广泛研究。然而，肌肉发育，稳态和再生需要与周围组织的相互作用，这种对话的细胞和分子方面尚未完全阐明。在发育和成年期，肌原细胞与不同类型的结缔组织密切相关。结缔组织被定义为特化（骨和软骨）、致密规则（肌腱和韧带）和致密不规则结缔组织。由于鉴定了表征不同类型结缔组织的转录因子，结缔组织在肌肉形态发生中的作用已被研究。在这里，我们回顾了各种结缔组织在肌肉骨骼系统中的发展，并强调了它们在提供正确的肌肉形态发生所需的信息方面的重要作用，从成肌细胞分化的早期阶段到肌肉成熟的后期阶段。肌肉和结缔组织之间的相互作用在成人肌肉再生过程中也是至关重要的，因为损伤后或神经肌肉疾病中再生潜力的受损导致肌肉质量被纤维化组织进行性替代。我们的结论是，肌肉和结缔组织之间的双向通信是至关重要的正确组装的肌肉骨骼系统在发展过程中，以及维持其稳态的成人。
Skeletal muscles belong to the musculoskeletal system, which is composed of bone, tendon, ligament and irregular connective tissue, and closely associated with motor nerves and blood vessels. The intrinsic molecular signals regulating myogenesis have been extensively investigated. However, muscle development, homeostasis and regeneration require interactions with surrounding tissues and the cellular and molecular aspects of this dialogue have not been completely elucidated. During development and adult life, myogenic cells are closely associated with the different types of connective tissue. Connective tissues are defined as specialized (bone and cartilage), dense regular (tendon and ligament) and dense irregular connective tissue. The role of connective tissue in muscle morphogenesis has been investigated, thanks to the identification of transcription factors that characterize the different types of connective tissues. Here, we review the development of the various connective tissues in the context of the musculoskeletal system and highlight their important role in delivering information necessary for correct muscle morphogenesis, from the early step of myoblast differentiation to the late stage of muscle maturation. Interactions between muscle and connective tissue are also critical in the adult during muscle regeneration, as impairment of the regenerative potential after injury or in neuromuscular diseases results in the progressive replacement of the muscle mass by fibrotic tissue. We conclude that bi-directional communication between muscle and connective tissue is critical for a correct assembly of the musculoskeletal system during development as well as to maintain its homeostasis in the adult.