DNA methylation and apoptosis resistance in cancer cells.
DNA methylation and apoptosis resistance in cancer cells.
复制标题
癌细胞中的DNA甲基化和凋亡性。
DOI：
10.3390/cells2030545
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发表时间：
2013-07-18
期刊：
影响因子：
6
通讯作者：
Cartron PF
中科院分区：
文献类型：
--
作者：
Hervouet E;Cheray M;Vallette FM;Cartron PF
细胞凋亡是一种细胞死亡程序，对细胞内稳态效率至关重要。这种正常的细胞自杀程序是响应死亡刺激而激活一系列事件的结果。细胞凋亡发生在正常细胞中，以维持细胞增殖和细胞死亡之间的平衡。由于代谢途径的改变而导致的这种平衡的失调导致不同的人类疾病，包括癌症。凋亡抵抗是肿瘤的重要标志之一，一些新的治疗策略集中在诱导癌细胞的细胞死亡。然而，癌细胞对诱导细胞死亡的治疗具有抗性，这是由于不同的机制，例如编码促凋亡蛋白的基因中的DNA突变、抗凋亡蛋白和/或促存活信号的表达增加、或由DNA超甲基化介导的促凋亡基因沉默。在这种情况下，异常的DNA甲基化模式，高甲基化和低甲基化的基因编码的蛋白质参与细胞凋亡途径是癌细胞耐药的可能原因。本文综述了肿瘤相关基因DNA甲基化在肿瘤细胞耐药中的作用。
Apoptosis is a cell death programme primordial to cellular homeostasis efficiency. This normal cell suicide program is the result of the activation of a cascade of events in response to death stimuli. Apoptosis occurs in normal cells to maintain a balance between cell proliferation and cell death. A deregulation of this balance due to modifications in the apoptosic pathway leads to different human diseases including cancers. Apoptosis resistance is one of the most important hallmarks of cancer and some new therapeutical strategies focus on inducing cell death in cancer cells. Nevertheless, cancer cells are resistant to treatment inducing cell death because of different mechanisms, such as DNA mutations in gene coding for pro-apoptotic proteins, increased expression of anti-apoptotic proteins and/or pro-survival signals, or pro-apoptic gene silencing mediated by DNA hypermethylation. In this context, aberrant DNA methylation patterns, hypermethylation and hypomethylation of gene coding for proteins implicated in apoptotic pathways are possible causes of cancer cell resistance. This review highlights the role of DNA methylation of apoptosis-related genes in cancer cell resistance.