Association study of polymorphisms in miRNAs with T2DM in Chinese population.
Association study of polymorphisms in miRNAs with T2DM in Chinese population.
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DOI：
10.7150/ijms.12954
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发表时间：
2015
影响因子：
3.6
通讯作者：
Yao Y
中科院分区：
文献类型：
--
作者：
Li Y;Zhang Y;Li X;Shi L;Tao W;Shi L;Yang M;Wang X;Yang Y;Yao Y
越来越多的证据表明，microRNA （miRNA或miR）参与了2型糖尿病（T2DM）的发展。一些研究表明，位于mirna中的单核苷酸多态性（snp）与高加索人群的2型糖尿病有关。亚洲人miRNA snp与T2DM的相关性研究很少报道，高加索人和亚洲人之间存在明显的遗传差异。因此，本研究的重点是T2DM与中国汉族人群中5个mirna中的5个snp （miR-27a中的rs895819、miR-124a中的rss531564、miR-128a中的rs11888095、miR-194a中的rs3820455和miR-146a中的rs2910164）的关联。采用TaqMan方法对738例T2DM患者和610例非糖尿病患者进行基因分型。接下来，评估5个snp与T2DM和个体代谢性状之间的关系。我们的数据显示，miR-124a中rs531564的C等位基因可能对T2DM有保护作用（P=0.009， OR=0.758; 95%CI: 0.616-0.933）。相反，miR-146a中rs2910164的C等位基因可能增加发生T2DM的风险（P<0.001， OR=1.459; 95%CI: 1.244-1.712）。然而，这5个snp在T2DM或非糖尿病组中均未显示出与个体代谢特征的显著关联。我们的研究结果显示，miRNAs的遗传变异与中国汉族人群的T2DM易感性相关，这些结果强调了研究miRNAs变异对T2DM发病风险的功能影响的必要性。
Accumulated evidence indicates that microRNA (miRNA or miR) is involved in the development of type 2 diabetes (T2DM). Several studies have shown that single nucleotide polymorphisms (SNPs) located in miRNAs are associated with T2DM in Caucasian populations. The association studies of miRNA's SNPs with T2DM in Asian are rarely reported, and there are distinct genetic differences between Caucasian and Asian populations. The focus of this study, therefore, is the association of T2DM with five SNPs (rs895819 in miR-27a, rs531564 in miR-124a, rs11888095 in miR-128a, rs3820455 in miR-194a and rs2910164 in miR-146a) located in five miRNAs in a Han Chinese population. A total of 738 subjects with T2DM and 610 non-diabetic subjects were genotyped using the TaqMan method. Next, the associations between the five SNPs with T2DM and individual metabolic traits were evaluated. Our data showed that the C allele of rs531564 in miR-124a may protect against T2DM (P=0.009, OR=0.758; 95%CI: 0.616-0.933). Conversely, the C allele of rs2910164 in miR-146a may increase the risk of developing T2DM (P<0.001, OR=1.459; 95%CI: 1.244-1.712). However, these five SNPs did not exhibit significant associations with individual metabolic traits in either the T2DM or non-diabetic groups. Our results revealed that genetic variations in miRNAs were associated with T2DM susceptibility in a Han Chinese population, and these results highlight the need to study the functional effects of these variants in miRNAs on the risk of developing T2DM.