International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age
International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age
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DOI：
10.1016/j.ejca.2005.11.031
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发表时间：
2006-05-01
影响因子：
8.4
通讯作者：
Shimada, Hiroyuki
中科院分区：
文献类型：
--
作者：
Sano, Hideki;Bonadio, Jeffrey;Shimada, Hiroyuki
年龄已被用作外周神经母细胞肿瘤（pnt）患者的预后因素。最新的分析显示，最佳预后区分的截止时间约为18个月。国际神经母细胞瘤病理分类（INPC）根据对神经母细胞瘤和神经节神经母细胞瘤、结节的组织学指标（神经母细胞分化等级、有丝分裂-核裂指数）的年龄评估来区分有利和不利的组织学。本研究表明，使用3个不同的截止点（12、18、24个月）测试的年龄具有预后意义。无论应用于哪个年龄组，INPC都具有重要的预后意义。年龄和组织学指标对预后的影响是独立显著的，即年龄的预后能力高于组织学指标，组织学指标的预后能力高于年龄。由于INPC在系统中纳入了年龄因素（18,60个月），因此它比年龄本身更能用于pNT患者的预后区分。(c) 2006 Elsevier Ltd.版权所有。
Age has been used as a prognostic factor for patients with peripheral neuroblastic tumours (pNTs). The latest analysis disclosed a cut-off around 18 months for the optimal prognostic distinction. The International Neuroblastoma Pathology Classification (INPC) distinguishes favourable and unfavourable histology based on the age-appropriate evaluation of histologic indicators (grade of neuroblastic differentiation, mitosis-karyorrhexis index) in the categories of neuroblastoma and ganglioneuroblastoma, nodular. This study showed that age tested by using 3 different cut-offs (12, 18, 24 months) was prognostically significant. INPC remained prognostically significant regardless of the age group to which it was applied. Prognostic effects of age and histologic indicators were independently significant, i.e., age had prognostic ability beyond that of histologic indicators, and histologic indicators had prognostic ability beyond that of age. Due to the fact that INPC incorporated age factor (18, 60 months) in the system, it served better than age by itself for prognostic distinction of pNT patients. (c) 2006 Elsevier Ltd. All rights reserved.