The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.
The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.
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DOI：
10.1371/journal.pone.0073659
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Davidson DJ
中科院分区：
文献类型：
--
作者：
Currie SM;Findlay EG;McHugh BJ;Mackellar A;Man T;Macmillan D;Wang H;Fitch PM;Schwarze J;Davidson DJ
呼吸道合胞病毒是婴儿、老年人和免疫功能低下者下呼吸道疾病的主要原因。目前，没有有效的疫苗或疾病修饰治疗，迫切需要新的干预措施。Cathelicidins是在发炎的肺中表达的阳离子宿主防御肽，在宿主对感染的先天防御中具有关键作用。我们证明，人cathelicidin LL-37在体外对RSV具有有效的抗病毒活性，由截短的中心肽片段保留。LL-37防止上皮培养物中病毒诱导的细胞死亡，显著抑制新感染性颗粒的产生并减少感染的传播，具有针对病毒颗粒和上皮细胞的抗病毒作用。LL-37可能代表先天宿主防御RSV感染的重要靶向组分。LL-37表达的预防性调节和/或感染后合成类似物的使用可能代表未来针对RSV感染的新策略。
Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic host defence peptides expressed in the inflamed lung, with key roles in innate host defence against infection. We demonstrate that the human cathelicidin LL-37 has effective antiviral activity against RSV in vitro, retained by a truncated central peptide fragment. LL-37 prevented virus-induced cell death in epithelial cultures, significantly inhibited the production of new infectious particles and diminished the spread of infection, with antiviral effects directed both against the viral particles and the epithelial cells. LL-37 may represent an important targetable component of innate host defence against RSV infection. Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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